Moore PS; Keystone Symposia on Molecular and Cellular Biology: 1998 HIV Pathogenesis and Treatment.
Keyst Symp Mol Cell Biol Keyst Symp Mol Cell Biol. 1998 Mar 13-19; 36 (abstract no. 013).
Columbia University, New York, NY.
The 140 kbase KSHV coding region is composed of conserved portions found among all herpesviruses, interspersed with regions unique to KSHV and related rhadinoviruses. These unique regions encode a number of recognizable genes pirated during evolution from the host cell genome. Transcriptional mapping shows that genes expressed during virus latency (and which may play a role in tumorigenesis) cluster to these unique regions. Homologs to cellular proteins encoded by the virus include a cyclin capable of phosphorylating RB1 and several antiapoptotic proteins, including a functional IL6-like cytokine. The vIL6 may play an important role in AIDS-related lymphoproliferative disorders, including Castleman's disease. An additional virus protein, vIRF, inhibits interferon responses and induces transformation of NIH3T3 cells. Together with other pirated genes, these potential oncogenes may contribute to angioproliferative and lymphomatous disorders associated with KSHV infection. These potential oncogenes are functionally related to those found in other tumor viruses and may represent a viral defense against the antiviral activity of tumor suppressor pathways.
Publication Types:
Keywords:
- Cyclins
- Genes, Tumor Suppressor
- Giant Lymph Node Hyperplasia
- Herpesvirus 8, Human
- Interferons
- Interleukin-6
- Oncogenes
- Sarcoma, Kaposi
- Viral Proteins
- Virus Latency
- genetics
- virology
Other ID:
UI: 102236679
From Meeting Abstracts