Ogura H, Kobayashi H, Nagai K, Nishida T, Naito T, Tatsumi Y, Yokoo M, Arika T; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1996 Sep 15-18; 113 (abstract no. F78).
Kaken Pharmaceutical Company, LTD., Kyoto, Japan.
In a search for an antifungal agent, we have prepared a variety of new azolylamine derivatives with general formula (I) and measured in vitro activity. MIC values (micrograms/ml) were shown below. (Table: see text) We found that the cyclic amine having methylene group at the 3 position is necessary for a broad antifungal spectrum and a potent activity. KP-103 which has a (2R,3R)-absolute configuration and a 4-methylenepiperidine moiety, showed the most potent activity and significantly lower MIC values than clotrimazole (CTZ). (Table: see text).
Publication Types:
Keywords:
- Antifungal Agents
- Clotrimazole
- In Vitro
- KP 103
- Miconazole
- Microbial Sensitivity Tests
- Structure-Activity Relationship
- Triazoles
Other ID:
UI: 102234849
From Meeting Abstracts