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IRIS Toxicological Review of 2-Hexanone (External Review Draft)

Federal Register Notices
Contact
Amanda Persad
by phone at:   919-541-9781
by fax at:   919-541-2985
by email at:  persad.amanda@epa.gov
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Notice

Update [04/23] EPA announces the External Peer Review Meeting will be held on May 22, 2008 in an April 23, 2008 Federal Register Notice.

EPA announces the release of the Toxicological Review of 2-Hexanone in the March 3, 2008 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within the external review period (next 60 days) will be provided to the external peer reviewers prior to the meeting for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions. The deadline for comments is April 28, 2008.

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of 2-hexanone that will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
Background
2-Hexanone was nominated for IRIS assessment because of its frequent detection at sites nationwide and its occurrence as a byproduct of certain industrial processes. 2-Hexanone has been used as a solvent for lacquers, ink thinners, nitrocellulose, resins, oils, fats and waxes. The only U.S. producer of 2-hexanone, the Tennessee Eastman Company division of Eastman Kodak, discontinued its production of 2-hexanone in 1979 and sold its remaining reserves by 1981.

History/Chronology

Jan 2008EPA completes the Interagency Review of the 2-hexanone Toxicological Risk Assessment.
Feb 2008EPA releases the first assessment of 2-hexanone in the IRIS database for public comment and review in preparation for an External Peer Review.
May 2008An external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of 2-Hexanone (External Review Draft).

Next Steps

Following the public review and comment period, the draft Toxicological Review will be reviewed by an external expert peer review meeting, which will be announced in the Federal Register.

Downloads/Related Links

This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.

Related Link(s)

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select “Environmental Protection Agency” and the keyword “EPA-HQ-ORD-2008-0048” (for the docket ID).

Citation

U.S. EPA. IRIS Toxicological Review of 2-Hexanone (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, NCEA-S-2764, 2008.
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