Delhere M, Krischer J, Laurence TL, Roten S, Saurat JH, Hirschel B; International Conference on AIDS.
Int Conf AIDS. 1998; 12: 319-20 (abstract no. 22286).
Department of Dermatology, Geneva Hospital, Switzerland.
BACKGROUND: AIDS Clinical Trials Group (ACTG) criteria are widely used to follow-up HIV-related Kaposi's sarcoma (KS); they are based on macroscopic observation. Epiluminescent light microscopy (ELM) is a non invasive method designed to improve diagnostic accuracy of pigmented skin lesions. Vascular tumors also exhibited ELM features which can be precisely measured and followed. The aim of this study was to assess the suitability of ELM in KS as a tool for lesional follow-up during local and systemic treatments. METHODS: 50 AIDS-related KS lesions were prospectively evaluated using ACTG criteria and using ELM during local (cryotherapy, radiotherapy, laser) and systemic therapies (chemotherapy, HIV-1 protease inhibitors, beta-HCG). Macroscopical and ELM parameters were compared and correlated to histological findings. RESULTS: Evolution of KS lesion evolution as documented by ELM closely correlated which evolution as documented by ACTG criteria. Changes in ELM features were more sensitive than macroscopical analysis alone. In particular, ELM better allows to differentiates superficial post-inflammatory pigment deposition from the vascular components of KS lesions. CONCLUSION: ELM constitutes a safe and reproducible technique to follow-up KS lesions, in addition to the ACTG evaluation. It offers the advantage of better differentiation between post-inflammatory pigment deposition, from the vascular components of KS lesions.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- HIV Infections
- HIV Protease Inhibitors
- HIV Seropositivity
- Light
- Microscopy
- Pigmentation Disorders
- Sarcoma, Kaposi
Other ID:
UI: 102228325
From Meeting Abstracts