Grulich A, Olsen S, Hendry O, Luo K, Cooper DA, Moore PS, Kaldor JM; Australasian Society for HIV Medicine. Conference.
Annu Conf Australas Soc HIV Med. 1997 Nov 13-16; 9: 150 (poster no. P65).
National Centre in HIV Epidemiology and Clinical Research, Sydney.
OBJECTIVE: An association between antibodies to Kaposi's sarcoma herpesvirus (KSHV, human herpesvirus 8), and risk of KS has been shown in cross sectional studies, but whether KSHV serology predicts development of KS, and the route of transmission of KSHV, are unknown. METHODS: 130 men newly diagnosed with AIDS during 1991-93 were followed until 1996. At baseline, subjects were interviewed regarding sexual behaviour. Serum stored at time of recruitment was subsequently tested for antibodies to KSHV, as well as herpes simplex type 2 (HSV-2) and hepatitis A virus (HAV). Serum testing was performed blind to knowledge of KS status. A case-control analysis of risk factors for KSHV infection and a longitudinal analysis for KS development were performed. RESULTS: 52% of subjects were KSHV seropositive. The relative risk of KS development in KSHV seropositive subjects was 4.4 (95% CI 1.9-10). KSHV infected subjects reported twice as many sexual partners (p < 0.01) and were more likely to be HSV-2 seropositive (OR = 2.6, 95% CI 1.0-6.7). Insertive oroanal contact was the only sexual behaviour significantly related to risk of KSHV infection (OR = 2.8, 95% CI 1.2-6.7) and remained significant after adjusting for other sexual behaviours. Both HSV-2 and HAV serology were significantly related to anogenital but not insertive oroanal contact. CONCLUSION: KSHV seropositivity predicts development of KS. KSHV is sexually transmitted in homosexual men, and the specific association between HHV-8 and oroanal sexual contact suggests that faecal-oral transmission is the most likely route of transmission.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Cross-Sectional Studies
- Herpesviridae
- Herpesviridae Infections
- Herpesvirus 2, Human
- Herpesvirus 8, Human
- Homosexuality
- Humans
- Male
- Risk Factors
- Sarcoma, Kaposi
- Sexual Behavior
- Simplexvirus
Other ID:
UI: 102226393
From Meeting Abstracts