Boshoff C, Whitby D, Matthews S, Talbot SJ, Reeves J, Weiss RA; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 4th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 4th 1997 Wash DC. 1997 Jan 22-26; 4th: 217 (abstract no. S25).
Institute of Cancer Research, London, UK.
The non-random distribution of Kaposi's sarcoma (KS) in various populations and HIV risk groups suggests that a transmissible agent is essential in its pathogenesis. The rare occurrence of KS in HIV-2 compared to HIV-1 infected individuals further suggests that HIV-1 itself may also play a role in its pathogenesis: HIV-1 tat has previously been shown to promote angiogenesis. Kaposi's sarcoma-associated herpesvirus (or HHV-8) is the first infectious agent found to be present in all epidemiologic forms of the disease. Current first generation serologic assays show that KISH is not ubiquitous in the UK or in North America and is more common in those countries where KS is also found without HIV (e.g. Italy, Greece, Uganda). We have infected microvascular endothelial cells, human cord lymphocytes, cottontop tamarin and cynomolgous macaque PBMC's with KSHV. Despite KSHV encoding potential important oncogenes (including a functional cyclin D2-like protein) we have so far not transformed/immortalized any of the infected cells. We have established an animal model for primary effusion lymphoma (PEL) and are currently attempting such a model for KSHV/KS.
Publication Types:
Keywords:
- Animals
- Gene Products, tat
- Greece
- HIV Seropositivity
- HIV-1
- HIV-2
- Herpesvirus 8, Human
- Humans
- Italy
- Leontopithecus
- North America
- Sarcoma, Kaposi
- Uganda
Other ID:
UI: 102223060
From Meeting Abstracts