Davachi F, Ngoie K, Mayemba N, Tady MB; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 395 (abstract no. PO-B12-1561).
Department of Pediatrics, Mama Yemo Hospital, Kinshasa, Zaire.
OBJECTIVE: To determine the features and the clinical course of Kaposi's Sarcoma and its association with AIDS in African children. METHODS: We studied 6 boys and 2 girls, ages 18 months to 11 years (mean age 5 yrs), with chronic generalized lymphadenopathy who were admitted to Mama Yemo Hospital, Kinshasa, Zaire. HIV-ELISA, Western blot test and lymph node biopsy were performed on all children. RESULTS: ELISA and Western blot were positive in each child. Lymph node biopsy revealed characteristics of Kaposi's sarcoma: lymphatic and vascular proliferation, spindle cell formation and mononuclear cell infiltration. Clinically, 6 children presented with fever, 3 with pulmonary tuberculosis, 2 with pneumonia, 2 with gastrointestinal bleeding and one with hemoptysis. Progression in children with KS was rapid resulting in 3 deaths in the initial hospitalization. CONCLUSION: Lymphadenopathic variant of Kaposi's sarcoma in African children may be a presenting feature of AIDS. This neoplasia has an aggressive course invading lymph nodes, lungs and gastrointestinal tract. This series had a high association with tuberculosis.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Child
- Democratic Republic of the Congo
- Enzyme-Linked Immunosorbent Assay
- Female
- HIV Antibodies
- HIV Seronegativity
- HIV Seropositivity
- Humans
- Lung
- Lung Neoplasms
- Lymph Nodes
- Male
- Sarcoma, Kaposi
- Tuberculosis
- Tuberculosis, Pulmonary
- immunology
Other ID:
UI: 102204501
From Meeting Abstracts