Ossondo Nolm M, Etoundi-Mballa GA, Ndumbe P, Zekeng L, Ngu VA; International Conference on AIDS.

Int Conf AIDS. 1990 Jun 20-23; 6: 201 (abstract no. Th.A.324).

University Center for Health Sciences in Yaounde (Cameroon)

Kaposi's sarcoma is the frequently encountered malignant disease in AIDS, but the reason for this association is not clear. We have studied the association of HIV infection with Kaposi's sarcoma in Cameroon where the latter is relatively common. We tested 30 patients with Kaposi's sarcoma who were diagnosed during a six month period at the Central Hospital Yaounde and the University Teaching Hospital in Yaounde (Cameroon). All of them underwent clinical and paraclinical examinations to determine the form of the disease and the presence of any possible immunodeficiency. We looked for antibodies to HIV by the Enzygnost anti-HIV micro-elisa tests (Behring) and performed a histological analysis of the lesions in all of the patients. Of the 30 patients, 27 were male and 3 female. Histological typing (Templeton) was as follows: 23 were type I (mixed cellularity), 6 were type II (monocellulaity) and one was type III (anaplastic). The 23 type I patients were 17 nodular forms 1 florid, 4 infiltrative and 1 lymphadenopathic. The 6 type II patients were 2 florid forms and 4 infiltrative. The one type III patient was a florid form. There was no patient with overt signs of immunodeficiency and all of them were HIV antibody negative, even the aggressive forms. In conclusion, there has been no change in Kaposi's sarcoma since the advent of AIDS. Thus HIV infection appears to be only a cofactor in the apparition of Kaposi's sarcoma. The mechanism of appearance is still elusive and Kaposi's sarcoma appears to be a good model for studying the role of viral infection in the immune system and oncogenesis.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Cameroon
• Enzyme-Linked Immunosorbent Assay
• Female
• HIV Infections
• HIV Seropositivity
• Humans
• Male
• Sarcoma, Kaposi

Other ID:

• 10032490

UI: 102181884

From Meeting Abstracts