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NIAID HIV and Emerging Infectious Diseases Program

Healthy Volunteer Studies

Studies of healthy volunteers are crucial to the understanding and treatment of diseases. They provide a baseline for measuring the extent of disease and provide important information about the safety and effectiveness of various treatments.

There is no risk of contracting HIV/AIDS from any of these studies.

For questions about participating in any of these clinical studies, contact:

Patient Recruitment and Public Liaison Office
Toll Free: 1-800-411-1222
TTY: 1-866-411-1010
Se habla español.
Office hours: 8 am to 8 pm, Eastern Time

A Phase I Double-Blind, Placebo-Controlled, Dose-Escalating Study to Evaluate the Safety and Tolerability of Topical Nasal Poly-ICLC

(POLY - Protocol #08-I-0093)

Doctors at the National Institutes of Health (NIH) are conducting a new research study (08-I-0093) to test the safety of Poly-ICLC, a medication that is being studied for its ability to prevent infections from influenza and other viruses. This medication is squirted into the nose. Volunteers 18 – 70 years old who do not have any chronic medical problems, prior nasal surgery, allergies that require daily medications, or lung conditions like asthma may be eligible. This study consists of 3 – 5 visits and one telephone call, and lasts 28 days. NIH is recruiting patients residing in the Washington, DC, Maryland, and Virginia metropolitan area. Volunteers will be compensated.

Correlation of the Precursor Frequency of CD4 + Effector Memory T Cells with Induration Measured in the Tuberculin Skin Test

(TST - Protocol #06-I-0030)

NIH is conducting a research study to investigate the human immune response to tuberculosis infection. Volunteers over 18 years old who have not been treated for tuberculosis are eligible to participate. The study involves up to 6 visits for placement of a tuberculin skin test and follow-up blood tests. The study is recruiting patients residing in the Washington, DC, Maryland, and Virginia metropolitan area. Volunteers will be compensated.

The Influence of Concurrent Administration of Echinacea purpurea, Ginkgo Biloba, or Panax Ginseng on the Steady State Pharmacokinetic Profile of Lopinavir/Ritonavir in Healthy Volunteers

(HERBPK - Protocol #05-CC-0082) This study is currently on hold.

We are seeking male and female volunteers ages 18 – 50 years for a research study to determine whether the herbal supplements Echinacea purpurea, ginkgo biloba, and Panax ginseng change the body's reaction to the HIV protease inhibitor combination lopinavir/ritonavir. In order to participate, you must be in good health. Volunteers will be compensated.

Pharmacogenetics of Efavirenz Metabolism: Association of CYP2B6 Genotype and Prolonged Drug Exposure

(EFV2B6 - Protocol #06-CC-0006) This study is currently on hold.

We are seeking healthy male and female volunteers, 18 – 55 years of age for a research study to evaluate the effects of genetics on the metabolism of an anti-viral medicine called efavirenz. Volunteers will have blood drawn and a medical history and physical performed to determine if they are eligible for the study. In order to participate, you must be a non-smoker in good health, not HIV-infected, and not taking any chronic medications. Volunteers will be compensated.

Influence of MDR-1 Genotype on Indinavir and Saquinavir Pharmacokinetics in Healthy Volunteers

(MDR-1 - Protocol #03-CC-0052) This study is currently on hold.

We are seeking male and female volunteers ages 18 – 50 years for a research study to determine whether a particular type of gene (MDR-1) in the body can affect blood levels of two medicines, indinavir and saquinavir. Volunteers will have blood drawn on several occasions. In order to participate, you must be a non-smoker in good health, not HIV-infected, and not taking any chronic medications. Volunteers will be compensated.

For questions about participating in any of these clinical studies, contact:

Patient Recruitment and Public Liaison Office
Toll Free: 1-800-411-1222
TTY: 1-866-411-1010
Se habla español.
Office hours: 8 am to 8 pm, Eastern Time

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