Eosinophil-Derived Neurotoxin, an Antimicrobial Protein with Ribonuclease Activity, is an Immunostimulant
Description of Invention:
Eosinophil-derived neurotoxin (EDN) has in vitro anti-viral activity that is dependent on its ribonuclease activity. This invention discloses that EDN is a selective chemoattractant and activator of dendritic cells, resulting in dendritic cell migration, maturation, and the production of a wide variety of cytokines. Based on these potent chemotactic and activating effects on dendritic cells, EDN might be useful as a clinical immunoadjuvant for the promotion of immune responses to specific antigens of tumors or pathogenic organisms.
Cancer -Therapeutics-Immunomodulators and Immunostimulants Infectious Diseases -Therapeutics-Anti-Viral Cancer -Therapeutics Infectious Diseases -Therapeutics
For Additional Information Please Contact: David A. Lambertson Ph.D.
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