Description of Invention:
This mouse has been generated by targeted gene disruption. The mouse provides a model to investigate the function of the chemokine receptor CX3CR1, which is a proinflammatory receptor for the leukocyte chemoattractant CX3CL1 (aka fractalkine). As an example, the mouse is in use in the study of atherosclerosis. Further, the mouse may serve as a model study the role of the immune system during infection with pathogens as well as other immunologically mediated diseases and responses to tumors.
Inventors:
Philip Murphy (NIAID) Christopher Combadière (NIAID) Ji-Liang Gao (NIAID)
Patent Status:
DHHS Reference No. E-216-2003/0 -- Research Tool
Relevant Publication:
This mouse has been described in the publication "Decreased atheroscelerotic lesion formation in CX3R1/ApoE double knockout mice", Christophe Combadière et al., Circulation 2003 Feb 25;107(7):1009-1016.
Portfolios: Research Materials Cancer
Cancer -Diagnostics-In Vitro-DNA Based Cancer -Diagnostics
For Additional Information Please Contact: Robert M. Joynes J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)594-6565
Email: joynesr@mail.nih.gov
Fax: (301) 402-0220
