Immunoreceptors initiate signals leading to the activation of immune system against invasion pathogens. A number of soluble receptors, representing the extracellular ligand binding domains of the immunoreceptors, have been expressed using a recombinant bacteria expression and reconstitution system. This set of 21 plasmids, which can be used as immunological research reagents or to develop diagnostic tools, comprise the following:
Plasmid
Description
CD16-28b
Soluble CD16
CD94 (S34) - 30a
Soluble CD94 truncated at S34
CD94 (E51) - 30a
Soluble CD94 truncated at E51
NKG2A (109R) - 30a
Soluble NKG2A 109R construct
NKG2A (117G) - 30a
Soluble NKG2A 117G construct
TBRII-30a
Soluble type II TGF-beta receptor
C143-30a
Soluble KIR2DL2 receptor
NKG2D-22b
Soluble NKG2D receptor
ULBP-1-22-b
Soluble ULBP-1
ULBP-2-22-b
Soluble ULBP-2
ULBP-3-22b
Soluble ULBP-3
HLA-E-30a
Soluble HLA-E heavy chain
HLA-Cw3
Soluble HLA-Cw3 heavy chain
TREM-1-22b
Soluble TREM-1 receptor
TREM-2-22b
Soluble TREM-2 receptor
NKp30-22b
Soluble NKp30
NKp46-22b
Soluble NKp46
NKp44-22b
Soluble NKp44
Siglec-3-30a
Soluble Siglec-3
Siglec-5-30a
Soluble Siglec-5
Siglec-7-30a
Soluble Siglec-7
Inventors:
Peter Sun (NIAID)
Patent Status:
DHHS Reference No. E-305-2003/0
Portfolios: Research Materials Devices/Instrumentation
Devices/Instrumentation-Research Materials-Biologicals and Chemicals Devices/Instrumentation-Research Materials
For Additional Information Please Contact: Cristina Thalhammer-Reyero PhD MBA
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301) 435-4507
Email: thalhamc@mail.nih.gov
Fax: (301) 402-0220