Cloned Genome of Infectious Hepatitis C Virus of Genotype 2a and Uses Thereof
Description of Invention:
The current invention provides a nucleic acid sequence comprising the genome of infectious hepatitis C viruses (HCV) of genotype 2a. The encoded polyprotein differs from those of the infectious clones of genotypes 1a and 1b (U.S. Patent 6,153,421) by approximately thirty (30) percent. It covers the use of this sequence and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostic assays for HCV and the development of screening assays for the identification of antiviral agents for HCV. Additional information can be found in Yanagi et al. (1999), Virology 262, 250-263.
Inventors:
Jens Bukh (NIAID) Masayuki Yanagi (NIAID) Robert H. Purcell (NIAID) Suzanne U. Emerson (NIAID)
Patent Status:
DHHS Reference No. E-100-1999/0 --
U.S. Patent No. 7,084,266 issued 01 Aug 2006
U.S. Patent Application No. 11/451,212 filed 12 Jun 2006
