Methods For Treating Parasitic Infection Using Thiopeptides
Description of Invention:
This invention provides a method for treating a parasitic infection (when the parasite has a plastid-like organelle) with a thiopeptide. The parasitic infection may be caused by parasites of the Apicomplexa phylum, the Microspora phylum or the Ascetospora phylum. The thiopeptide used to treat the parasitic infection can be any member of the class of compounds characterized as sulfur-rich peptide antibiotics with multiple thiazole rings which inhibit protein synthesis in the plastid-like organelle of the parasites. The disclosed thiopeptides can be, but are not limited to, thiostrepin, micrococcin P, nosiheptide, siomycin, sporangiomycin, althiomycin, the thiocillins and/or thiopeptin, as well as sulfur-rich peptide antibiotic containing multiple thiazole rings, produced by streptomycetes or other peptide antibiotic-producing organisms.
Inventors:
MJ Rogers (NIAID) TF McCutchan (NIAID) GA McConkey (NIAID) A Fairfield (NIAID)
Patent Status:
DHHS Reference No. E-202-1997/0 --
PCT Application No. PCT/US97/11939 filed 07 Jul 1997, which published as WO 99/02176 on 21 Jan 1999
U.S. Patent Application No. 09/446,765 filed 20 Mar 2000, which issued as U.S. Patent 6,313,090 on 06 Nov 2001
For Additional Information Please Contact: Robert M. Joynes J.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
Rockville, MD 20852-3804
Phone: (301)594-6565
Email: joynesr@mail.nih.gov
Fax: (301) 402-0220
