Nucleotide And Deduced Amino Acid Sequences Of The Envelope-1 And Core Genes Of Isolates Of Hepatitis C Virus And Methods Of Use
Description of Invention:
This invention describes the complete nucleotide and deduced amino acid sequences of the envelope-1 (E1) and core genes of hepatitis C virus (HCV) isolates from around the world and the grouping of these isolates into fourteen distinct HCV genotypes. Specifically the invention relates to oligonucleotides, peptides, and recombinant proteins derived from the envelope-1 and core gene sequences of the HCV isolates and to diagnostic methods and vaccines which employ these reagents. Envelope polynucleotide sequences from 51 isolates and core sequences from 52 isolates were analyzed, along with their derived amino acid sequences. The invention is partially described in Proc. Natl. Acad. Sci. USA 89, 4942-4946 (1992), Proc. Natl. Acad. Sci. USA 90, 8234-8238 (1993), and Seminars in Liver Disease 15, 41-63 (1995).
Inventors:
J Bukh (NIAID) R Miller (NIAID) R Purcell (NIAID)
Patent Status:
U.S. Patent 5,882,852 issued 16 Mar 1999 (DHHS Reference No. E-032-1994/0-US-01)
U.S. Patent Application No. 09/084,691 filed 26 May 1998 (DHHS Reference No. E-032-1994/0-US-02)
Related Technologies:
U.S. Patent 6,110,465 issued 29 Aug 2000 (DHHS Reference No. E-032-1994/1-US-01)
For Additional Information Please Contact: Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd, Suite 325
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Phone: (301) 435-5515
Email: anos@mail.nih.gov
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