The correspondence section is a public forum and, as such, is not peer-reviewed. EHP is not responsible for the accuracy, currency, or reliability of personal opinion expressed herein; it is the sole responsibility of the authors. EHP neither endorses nor disputes their published commentary.
Exposure to Environmental Tobacco Smoke and Cognitive Abilities Among U.S. Children and Adolescents
[ citation in pubmed ]
In the article "Exposure to Environmental Tobacco Smoke and Cognitive Abilities Among U.S. Children and Adolescents," Yolton et al. (2005) stated that the data "indicate an inverse association between ETS exposure and cognitive deficits among children . . . ." They do not. They indicate an inverse association between ETS exposure and scores, but a direct association between ETS exposure and cognitive deficits.
The author declares he has no competing financial interests.
Phillip Petersen
Queensland Medical Laboratory and Queensland University of Technology
Rochedale, South Queensland, Australia
E-mail: philpetersen@optusnet.com.au
Reference
Yolton K, Dietrich K, Auinger P, Lanphear BP, Hornung R. 2005. Exposure to environmental tobacco smoke and cognitive abilities among U.S. children and adolescents. Environ Health Perspect 113:113:98-103.
Editor's note: In accordance with journal policy, Yolton et al. were asked whether they wanted to respond to this letter, but they chose not to do so.
Maternal and Paternal Risk Factors for Hypospadias
[ citation in pubmed ]
Hypospadias is a common congenital anomaly, characterized by incomplete fusion of the urethral folds during fetal development, which results in the urethra opening on the ventral surface of the penis or on the scrotum. In their article, Pierik et al. (2004) proposed multiple possible maternal and paternal risk factors related to the development of isolated hypospadias, including genetic, endocrine, and environmental factors.
Concerns and alarms have been raised about the potential effects of endocrine disruptors, which include derivatives of polyaromatic hydrocarbons and pesticides, on the developing male reproductive tract. We have recently published two case-control studies on risk factors and hypospadias, one on a possible association with maternal age (Bianca et al. 2005) and the other on the role of endocrine disruptors (Bianca et al. 2003).
In the first study (Bianca et al. 2005), we evaluated 415 newborns with isolated hypospadias and 812 controls. Our results suggest that an increased risk for hypospadias exists in women at the extremes of the age distribution (< 20 years and > 40 years; p = 0.000 and 0.026, respectively) relative to women in the middle of the distribution, with a mechanism probably related to hormonal disruption. It has been postulated that changes in concentrations of sex hormones during the fetal critical period of genital development (weeks 8-14), caused by endogenous or exogenous factors, may play a role in the development of hypospadias and that hypospadias could be associated with early malfunction of the placenta, resulting in decreased secretion of placental and fetal hormones that could in turn disturb fetal development (Akre et al. 1999). Mothers at the extremes of the age distribution may be more susceptible to this hormonal disruption. The association between hypospadias and maternal age, both for younger and older women, might be explained as a "defect in nature's quality control" caused by a reduction of defensive maternal mechanisms that would be less efficient in the elimination of malformed fetuses in the mothers of hypospadias cases. This hypothesis may also apply to other birth defects where a relationship with maternal age has been demonstrated.
In the second study of 68 cases and 211 controls (Bianca et al. 2003), we identified a high incidence of hypospadias in two towns in southeastern Sicily, which have intense industrial (Augusta) and agricultural (Vittoria) activities. Our results showed an incidence that was 3.8 [95% confidence interval (CI), 2.16-6.14] and 2.3 times (95% CI, 1.48-3.43) higher, respectively, than expected (3.2 per 1,000 male live births in southeastern Sicily). The odds ratios for fathers' job exposure alone were 5.5 (95% CI, 1.22-24.7) for working in an oil refinery in Augusta and 2.9 (95% CI, 1.01-8.55) for working in hothouses in Vittoria.
Pollutants in both areas include compounds with proven estrogenic activity and other chemicals: pesticides and herbicides and their metabolites; dieldrin, chlordane, and endosulfan; polychlorinated biphenyls and dioxins; bisphenols used in epoxy resins; and some phthalates used as plasticizers in a wide variety of applications, including polyvinyl compounds and alkyphenol ethoxylates. The direct cause-effect relationship between environmental pollutants, which act as endocrine disruptors, and the increased incidence of hypospadias in these areas is difficult to establish and demonstrate. Our study (Bianca et al. 2003), suggested that exposure to large amounts of industrial and agricultural pollutants is sufficient to increase the risk of hypospadias.
Other risk factors, such as reproductive history, may be involved in the etiology of hypospadias. Disturbances in sexual differentiation occur when endogenous and/or exogenous factors act to disrupt the metabolism of gonadal hormones during development.
Further epidemiologic and biologic studies are needed to explain, in a multifactorial model, which factors (genetic and/or environmental) interact and influence the etiology of this congenital abnormality.
The authors declare they have no competing financial interests.
Sebastiano Bianca
Carmela Ingegnosi
Dipartimento Materno Infantile
Centro di Consulenza Genetica e di Teratologia della Riproduzione
ARNAS, P.O. Garibaldi Nesima
Catania, Italy
E-mail: sebastiano.bianca@tiscali.it
Giuseppe Ettore
Dipartimento Materno Infantile
U.O. Ginecologia e Ostetricia
ARNAS, P.O. Garibaldi Nesima
Catania, Italy
References
Akre O, Lipworth L, Cnattingius S, Sparen P, Ekbom A. 1999. Risk factor patterns for cryptorchidism and hypospadias. Epidemiology 10:364-369.
Bianca S, Ingegnosi C, Ettore G. 2005. Maternal age and hypospadias. Acta Obstet Gynecol Scand 84:410.
Bianca S, Li Volti G, Caruso-Nicoletti M, Ettore G, Barone P, Lupo L, et al. 2003. Elevated incidence of hypospadias in two Sicilian towns where exposure to industrial and agricultural pollutants is high. Reprod Toxicol 17: 539-545.
Pierik FH, Burdorf A, Deddens JA, Juttmann RE, Weber RFA. 2004. Maternal and paternal risk factors for cryptorchidism and hypospadias: a case-control study in newborn boys. Environ Health Perspect 112:1570-1576.
Editor's note: In accordance with journal policy, Pierik et al. were asked whether they wanted to respond to this letter, but they chose not to do so.
Table 1.
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Errata
In Table 1 of "Estimating the Exposure-Response Relationships between Particulate Matter and Mortality within the APHEA Multicity Project" by Samoli et al. [Environ Health Perspect 113:88-95 (2005)], the values for CVD deaths are incorrect. The corrected table is shown below. The authors apologize for the errors.
Bonner et al. would like to correct a factual error in "Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study" [Environ Health Perspect 113:285-289 (2005)]. In the second paragraph of the introduction, the fourth sentence was incorrect. The two studies cited demonstrated that another carbamate pesticide, carbendazim, and not carbofuran, induced lymphoma. The sentence should read: "While two studies demonstrated that the carbamate pesticide carbendazim was able to induce lymphoma in Swiss mice (Borzsonyi and Pinter 1977; Borzsonyi et al. 1976), carcinogenicity of carbofuran was not evident in several 2-year dietary studies conducted on rats (Gupta 1994)."
Despite the error, the authors stand by the validity of the analysis and the interpretation of the results. The authors apologize for the error.
The March Focus article ["Great Lakes: Resource at Risk," Environ Health Perspect 113: A164-A173 (2005)] stated that Dow Chemical released about 400 tons of mercury into Lake Superior from two chloralkali plants. In fact, these two plants were located in Sarnia, Ontario. Thus, the discharges were made into Lake Huron. EHP regrets the error.