Laboratory of Allergic Diseases
Dean D. Metcalfe, M.D., Chief
The Laboratory of Allergic Diseases (LAD) conducts basic and clinical research on immunologic diseases with an emphasis on disorders of immediate hypersensitivity, which include the spectrum of classic allergic diseases. LAD is composed of an interactive group of Ph.D.s., M.D.s., research nurses, technicians, and administrative staff, who work in contemporary laboratories adjacent to NIAID's clinical facilities. Scientific personnel are engaged in research aimed at elucidating events in mast-cell-dependent, IgE-mediated allergic inflammatory reactions.
Basic research efforts are directed at studying the growth, differentiation and activation of mast cells, basophils, and eosinophils; animal models of allergic inflammation; mast cell surface receptors; signal transduction pathways in inflammation; and the biological manifestations of effector-cell activation in tissues.
Clinical research is directed toward understanding the pathogenesis of allergic inflammation and the role of mast cells, basophils, eosinophils, and T lymphocytes and their cytokines in this process. Efforts are then undertaken to translate basic and clinical research findings into novel immunomodulatory and anti-inflammatory approaches to the treatment of allergic and immunologic disorders, including anaphylaxis, eosinophilic gastrointestinal diseases, and systemic mast cell disorders.
Office of the Chief
Dean D. Metcalfe, M.D., Chief
Adverse Reactions to Vaccines and Biologics Unit
Calman Prussin, M.D.
Pediatric Allergy Clinic
Hirsh Komarow, M.D.
Helene F. Rosenberg, M.D., Ph.D.
Kimberly D. Dyer, Ph.D.
Dean D. Metcalfe, M.D.
Alasdair M. Gilfillan, Ph.D.
Melody C. Carter, M.D.
Arnold S. Kirshenbaum, M.D.
Molecular Signal Transduction Section
Kirk M. Druey, M.D.
Allergy and Immunology Clinical Training Program
Kelly D. Stone, M.D., Ph.D.
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