Stage I Prostate Cancer
Stage II Prostate Cancer
Stage III Prostate Cancer
Stage IV Prostate Cancer

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Treatment of stage I prostate cancer may include the following:

• Watchful waiting.
• Radical prostatectomy, usually with pelvic lymphadenectomy, with or without radiation therapy after surgery. It may be possible to remove the prostate without damaging nerves that are necessary for an erection.
• External-beam radiation therapy.
• Implant radiation therapy.
• A clinical trial of high-intensity focused ultrasound.
• A clinical trial of radiation therapy.
• A clinical trial testing new types of treatment.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage I prostate cancer.

Treatment of stage II prostate cancer may include the following:

• Radical prostatectomy, usually with pelvic lymphadenectomy, with or without radiation therapy after surgery. It may be possible to remove the prostate without damaging nerves that are necessary for an erection.
• Watchful waiting.
• External-beam radiation therapy with or without hormone therapy.
• Implant radiation therapy.
• A clinical trial of radiation therapy with or without hormone therapy.
• A clinical trial of ultrasound -guided cryosurgery.
• A clinical trial of hormone therapy followed by radical prostatectomy.
• A clinical trial testing new types of treatment.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage II prostate cancer.

Treatment of stage III prostate cancer may include the following:

• External-beam radiation therapy with or without hormone therapy.
• Hormone therapy.
• Radical prostatectomy, usually with pelvic lymphadenectomy, with or without radiation therapy after surgery.
• Watchful waiting.
• Radiation therapy, hormone therapy, or transurethral resection of the prostate as palliative therapy to relieve symptoms caused by the cancer.
• A clinical trial of radiation therapy.
• A clinical trial of ultrasound -guided cryosurgery.
• A clinical trial testing new types of treatment.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage III prostate cancer.

Treatment of stage IV prostate cancer may include the following:

• Hormone therapy.
• External-beam radiation therapy with or without hormone therapy.
• Radiation therapy or transurethral resection of the prostate as palliative therapy to relieve symptoms caused by the cancer.
• Watchful waiting.
• A clinical trial of radical prostatectomy with orchiectomy.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage IV prostate cancer.

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