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en español
Genetic
Characterization
and Sequencing
Wild-type measles viruses have been divided into distinct genetic groups
according to the nucleotide sequences of their hemagglutinin (H) and nucleoprotein
(N) genes, which are the most variable genes on the viral genome.
The nucleotide
sequence encoding the carboxy-terminus
 (text-only) of
the nucleoprotein (the last 450 nucleotides) has up to 12% nucleotide
variation between the most dissimilar genotypes.
For each
genetic grouping or genotype, a reference
strain (text-only) is
designated for use in genetic analysis (phylogenetic analysis), usually
the earliest known virus isolation of that group. The means of referring
to the genotypes has been standardized using alphabetical designations
for the main groupings (clades). Within the main groups, numerals are
added for closely related, but distinct groups that exist or are encountered
as more viruses are sequenced.
Viruses
with these genotypes have been isolated since 1990:
A, B3,
C1, C2, D2, D3, D4, D5, D6, D7, D8, G2, H1, H2, D9, G3, B2, D10
Citation list of journal articles on measles genotyping and sequencing (text-only)
National
Center for Biotechnology Information (NCBI) GenBank (exit site). Guidelines for naming strains or sequences
have been developed so that a consistent genetic designation and analysis
protocol can be applied by all investigators when communicating data about
measles viruses. |
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