Prevention of Immune-Mediated Graft Rejection
The major goals of NIAID’s transplantation research program are to understand the pathways whereby the immune system recognizes transplanted organs, tissues, and cells; characterize the cellular and molecular components of acute rejection and chronic graft failure; evaluate novel therapies for treating rejection and prolonging graft survival in preclinical models; develop and implement strategies for immune tolerance induction; and conduct clinical trials of new therapies to improve graft survival, while minimizing the toxic side effects of immunosuppressive drugs.