Research Project:
DEVELOPMENT OF NATURAL PRODUCTS FROM PLANTS AND MICROBES FOR REPLACEMENT OF SYNTHETIC PESTICIDES
Location: Natural Products Utilization Research
Project Number: 6408-21410-007-02
Project Type:
Specific Cooperative Agreement
Start Date: Nov 21, 2001
End Date: Oct 31, 2006
Objective:
The overall goal of this project is to discover, develop and foster commercialization of new bioactive natural products as new pharmaceuticals or agrichemicals, and to identify, characterize, and develop plants for production of pharmaceuticals or pesticides as potential alternative crops.
Approach:
The approach includes a program of: (1) Development of strategies for rational collection of terrestrial, aquatic, and marine plants, as well as microbes, as a source of novel bioactive natural products. (2) Discovery and development of novel pharmaceutically or agriculturally useful natural products from higher plants. (3) Identification and investigation of new mechanistic targets that may be used in the discovery of pesticides and anti-infective agents. (4) Development of methods and technologies to authenticate, pharmacologically characterize, and chemically analyze higher plants as sources of pharmaceuticals or botanical supplements. (5) Investigations of selections, cloning, propagation, agronomics, cultivation, harvesting, and processing of medicinal plants in relation to the chemistry of desired pharmaceutically or agriculturally useful natural products.
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