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Publications from SELECT

Introduction

SELECT (the Selenium and Vitamin E Cancer Prevention Trial) is the largest-ever prostate cancer prevention trial. Previous studies suggest that selenium and vitamin E (alone or in combination) may reduce the risk of developing prostate cancer by 60 percent and 30 percent, respectively, but only a large clinical trial such as SELECT can confirm those initial findings.

SELECT began enrolling patients on August 22, 2001, and closed enrollment on June 24, 2004, with 35,534 participants. About 15 percent of the participants are African-American.

The study includes men 55 and older. African-American men, 50 and over, were eligible to enroll because prostate cancer strikes African-American men earlier and more often than white men. There are 435 SELECT sites throughout the United States, Puerto Rico, and Canada.

Coordinated by a network of researchers called the Southwest Oncology Group (SWOG), the study is sponsored by the National Cancer Institute (NCI).

SWOG maintains a Web page with information about SELECT ², including a list of participating sites.

To get more information about SELECT or to locate a participating center, call 1-800-4-CANCER in the United States and Puerto Rico or 1-888-939-3333 in Canada.

About SELECT
Selenium and Vitamin E Cancer Prevention Trial (SELECT): Questions and Answers ³
(Reviewed: 06/13/2005) - A fact sheet that describes a clinical trial designed to determine if selenium and/or vitamin E can prevent prostate cancer. National Cancer Institute Fact Sheet 4.20

Largest-Ever Prostate Cancer Prevention Trial Opens: 32,000 Men Sought to Test Vitamin E and Selenium ⁴
(Posted: 07/24/2001) - Healthy men age 55 and older are needed for the largest-ever prostate cancer prevention study, launched today by the NCI and a network of researchers known as the Southwest Oncology Group (SWOG). Questions and Answers ⁵

Phase III Randomized Study of Selenium and Vitamin E for the Prevention of Prostate Cancer (SELECT Trial) ⁶
A summary of the SELECT protocol statement.

SELECT Data: Enrollment Statistics ⁷
(Updated: 09/04/2003) - Enrollment data from SELECT, the Selenium and Vitamin E Cancer Prevention Trial.
About SELECT (Español)
Estudio del Selenio y la Vitamina E para Prevenir el Cáncer (SELECT): preguntas y respuestas ⁸
(Revisión: 06/28/2005) - Esta es la versión en español de una hoja informativa que responde preguntas acerca de un estudio clínico para ver si el selenio o la vitamina previenen el cáncer de próstata. Hoja informativa 4.20s del Instituto Nacional del Cáncer/This is the Spanish version of a fact sheet that answers questions about a clinical trial to see if Selenium or Vitamin E prevent prostate cancer in men. National Cancer Institute Fact Sheet 4.20s

Se inagura estudio de prevención de cáncer de próstata ⁹
(Publicación: 07/24/2001) - Más de 400 centros en los Estados Unidos, Puerto Rico y Canadá están aceptando participantes para SELECT. Este estudio durará 12 años. SELECT es el primer estudio diseñado para observar directamente los efectos del selenio y la vitamina E, tanto juntos como por separado, para prevenir el cáncer de próstata.
About Other Prostate Cancer Prevention Trials
Prostate Cancer Prevention Trial (PCPT): Questions and Answers ¹⁰
(Posted: 06/24/2003, Updated: 05/18/2008) - In the Prostate Cancer Prevention Trial (PCPT), 25 percent fewer men taking the drug finasteride developed prostate cancer than men not taking the drug. However, men who developed prostate cancer while taking finasteride were more likely to have high-grade cancers, which can spread quickly even if the tumors are small.
About Other Vitamin E Trials
HOPE-TOO: NCI Comment on Published Results ¹¹
(Posted: 03/15/2005) - A report published in the March 16 issue of the Journal of the American Medical Association finds no clear evidence that men and women who had vascular disease or diabetes and who took 400 i.u. of vitamin E daily for 7 years reduced their risk of cancer compared to others with these conditions who took a placebo.
About Prostate Cancer Prevention
Prostate Cancer Prevention (PDQ®)
[ patient ] ¹² [ health professional ] ¹³
Expert-reviewed information summary about factors that may influence the risk of developing prostate cancer and about research aimed at the prevention of this disease.

Best Leads for Prostate Cancer Prevention Appear in April Urology Supplement; Agents, Biomarker Endpoints, Cohorts, and Trial Designs Outlined ¹⁴
(Posted: 04/09/2001) - The most promising agents to prevent prostate cancer and the most likely biological markers of risk for the disease are just two of the key areas of prostate cancer prevention research highlighted.
Other Materials

SELECT Home Page ¹⁵
Up-to-date information about the SELECT trial from the Southwest Oncology Group (SWOG), including contact information for men interested in participating.

Prevention and Early Detection Clinical Trials: Opportunities for Primary Care Providers and Their Patients
(Posted: 03/18/2003) - A paper published in the March/April 2003 issue of CA: A Cancer Journal for Clinicians examines some of the barriers to participation in prevention and early detection trials and provides information about various trials now open for enrollment.
Current Clinical Trials

Prevention of Prostate Cancer ¹⁶
List of open clinical trials investigating ways to prevent to prostate cancer, or to prevent a recurrence or progression of prostate cancer, from NCI's clinical trials database.
Publications from SELECT

The following citations are of reports that have been published in the scientific literature concerning the Selenium and Vitamin E Cancer Prevention Trial (SELECT). The citations are listed in reverse chronological order.

2005 Publications

Designing the selenium and vitamin E cancer prevention trial (SELECT) ¹⁷

• Authors: SM Lippman; PJ Goodman; EA Klein; HL Parnes; IM Thompson, Jr; AR Kristal; RM Santella; JL Probstfield; CM Moinpour; D Albanes; PR Taylor; LM Minasian; A Hoque; SM Thomas; JJ Crowley; JM Gaziano; JL Stanford; ED Cook; NE Fleshner; MM Lieber; PJ Walther; FR Khuri; DD Karp; GG Schwartz; LG Ford; CA Coltman, Jr.
• Journal: Journal of the National Cancer Intitute 97(2):94-102. (2005).

2004 Publications

Introducing HIPPAA: triple the cost and triple and time for patient recruitment to the SELECT study

• Authors: NS Gorby; MS Wolf; CL Bennett.
• Journal: Proc of the American Society of Clinical Oncology 23:519 (#6009). (2004).

Prostate cancer chemoprevention: an overview of United States trials ¹⁸

• Authors: A Barqawi; IM Thompson; ED Crawford.
• Journal: Journal of Urology 171:S5-S9. (2004).

2003 Publications

Challenges of implementing ancillary studies within multi-site clinical trials

• Authors: T Chay; P Goodman; J Hartline.
• Journal: Controlled Clinical Trials 24(3S)Suppl:182S(#P173). (2003).

Drug distribution challenges in a multi-site clinical trial

• Authors: A Darke; J Vertrees; P Goodman.
• Journal: Controlled Clinical Trials 24(3S)Suppl:203S(#P217). (2003).

Effectiveness of a media-based launch to recruit to a prostate cancer prevention trial

• Authors: L Minasian; K Smigel-Croker; A Ryan; A Voss; L Cave; E Klein; L Ford.
• Journal: Controlled Clinical Trials 24(3S)Suppl:50S (#14). (2003).

Form and function: PDF+ versus HTML form design

• Authors: K Gower; B Kleinman.
• Journal: Controlled Clinical Trials 24(3S)Suppl:188A(#P186). (2003).

Optimizing data collection in a large web-based trial

• Authors: KB Gower; A Darke.
• Journal: Controlled Clinical Trials 24(3S):47S(#10). (2003).

Planning for successful recruitment for cancer trials

• Authors: K Anderson; J Probstfield; SM Thomas.
• Journal: Controlled Clinical Trials 24(3S)Suppl:102S(#P18). (2003).

2002 Publications

The challenges and benefits of a web-based trial

• Authors: B Kleinman; A Darke; JA Hartline.
• Journal: Controlled Clinical Trials 23(2S):91S-92S(#P.62). (2002).

The Das/Kaplan article reviewed: The role of PC-SPES, selenium, and Vitamin E in prostate cancer ¹⁹

• Author: EJ SMall.
• Journal: Oncology 16(3):291-300. (2002).

2001 Publications

Molecular epidemiologic studies within the selenium and vitamin E cancer prevention trial (SELECT) ²⁰

• Authors: A Hoque; D Albanes; SM Lippman; MR Spitz; PR Taylor; EA Klein; IM Thompson; P Goodman; JL Stanford; JJ Crowley; CA Coltman; RM Santella.
• Journal: Cancer Causes and Control 12:627-633. (2001).

SELECT: The next prostate cancer prevention trial ²¹

• Authors: EA Klein; IM Thompson; SM Lippman; PJ Goodman; D Albanes; PR Taylor; C Coltman.
• Journal: Journal of Urology 166:1311-1315. (2001).

The web-based management of the selenium and vitamin E cancer prevention trial

• Authors: PA Shaw; PJ Goodman; J Brace.
• Journal: Controlled Clinical Trials 22(2S):57S(#P06). (2001).

2000 Publications

SELECT: The selenium and vitamin E cancer prevention trial: rationale and design ²²

• Authors: EA Klein; IM Thomposn; S Lippman; P Goodman; D Albanes; PR Taylor; C Coltman.
• Journal: Prostate Cancer and Prostatic Diseases 3:145-151. (2000).