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2004 Progress Report: Ultrafine Particles: Characterization, Health Effects and Pathophysiological Mechanisms
EPA Grant Number: R827354Center: Airborne PM - Rochester PM Center
Center Director: Oberdorster, Gunter
Title: Ultrafine Particles: Characterization, Health Effects and Pathophysiological Mechanisms
Investigators: Oberdörster, Günter , Beckett, William , Cass, Glen , Cox, Christopher , Ensor, David , Finkelstein, Jacob N. , Frampton, Mark W. , Heyder, Joachim , Looney, John , Marder, Victor J. , Morrow, P. E. , O'Reilly, Michael , Peters, Annette , Phipps, Richard , Prather, Kimberly A. , Schwarz, Edward , Sharp, Zachary , Stripp, Barry , Utell, Mark J. , Wichmann, Heinz-Erich , Yu, C. P. , Zareba, Wojciech
Institution: University of Rochester , GSF- Institute for Epidemiologie , Georgia Institute of Technology , Research Triangle Institute , University of California - Los Angeles , University of California - San Diego
EPA Project Officer: Stacey Katz/Gail Robarge,
Project Period: June 1, 1999 through May 31, 2005 (Extended to May 31, 2006)
Project Period Covered by this Report: June 1, 2003 through May 31, 2004
Project Amount: $8,302,447
RFA: Airborne Particulate Matter (PM) Centers (1999)
Research Category: Particulate Matter
Description:
Objective:The objective of this research project is to test the hypothesis that ultrafine particles occurring in the urban atmosphere cause adverse health effects. Epidemiological studies have consistently found an association between small increases in urban particulates and health effects, including increased morbidity and mortality in people with respiratory and cardiac disease. The observed effects are associated with the fine rather than the coarse particles in the atmosphere. Moreover, animal studies have shown that ultrafine particles have a significantly greater pulmonary inflammatory potency than larger submicronic particles. A recent epidemiological study found that particle number—reflecting ambient ultrafine particles—correlated better than fine particle mass with increased symptoms in asthmatics. These results form the basis for the ultrafine particle hypothesis. The proposed studies are designed to rigorously test the ultrafine particle hypothesis by comparing ultrafine (~10-50 nm) with accumulation mode particles (~100-500 nm) in all phases of this research. The objectives, which will be addressed by five interactive research cores in the Rochester Particulate Matter (PM) Center over a 5-year study period, are to: (1) determine the number, mass concentration, and composition of urban ultrafine and accumulation mode particles of an eastern and western U.S. city; (2) evaluate the association between ambient particle number/mass concentrations and respiratory as well as cardiovascular effects in a susceptible cohort; (3) compare exposure-dose-response relationships for respiratory and cardiovascular endpoints between ultrafine and accumulation mode particles in controlled clinical and animal studies; (4) assess the significance of factors enhancing ultrafine particle effects: age, disease, co-pollutants, pre-exposure history, and exercise; (5) measure total and regional deposition of ultrafine particles in the lower respiratory tract of rodents and total deposition in humans for purposes of extrapolation modeling between species and for in vitro dosing; (6) perform mechanistic studies at a cellular and molecular level to test the hypothesis that ultrafine particle effects are due to oxidative stress induced events; (7) support the development of an ambient ultrafine particle concentrator and test the feasibility for its use in controlled in vitro, animal, and clinical studies; and (8) coordinate research efforts and dissemination of results with other centers.
Progress Summary:The five research cores that will address the objectives of this study include the following: Characterization of the Chemical Composition of Atmospheric Ultrafine Particles (Hopke, et al.); Inflammatory Responses and Cardiovascular Risk Factors in Elderly Subjects With Angina Pectorus or Chronic Obstructive Pulmonary Disease (COPD) in Association With Fine and Ultrafine Particles (Wichmann, et al.); Clinical Studies of Ultrafine Particle Exposure in Susceptible Human Subjects (Frampton and Utell); Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events (Oberdörster, et al.); Ultrafine Particle Cell Interactions: Molecular Mechanisms Leading to Altered Gene Expression (Finkelstein, et al.).
Additional information on the accomplishments of the research cores can be found in the individual annual project summaries for R827354C001, R827354C002, R827354C003, R827354C004, and R827354C005.
Future Activities:A prototype ultrafine particle concentrator will be developed, which will be capable of concentrating urban ultrafine particles (UP, <0.1 µm) for use in toxicological studies at ambient pressure. In support of improvements in risk assessment or risk management, it is expected that the Center will uncover specific cellular and molecular mechanisms, which can explain the progression of ultrafine particle-induced pulmonary responses to vascular and cardiac events. Confirmation of the ultrafine particle hypotheses will have significant consequences for public health and regulatory PM standards and lead to important improvements in risk assessment and risk management. Not only will the new PM2.5 standard have to be reevaluated, but an additional standard defined by particle number needs to be considered. Furthermore, sources of ultrafine particles (e.g., combustion engines, residential natural gas heating) may require further regulation.
Journal Articles: 78 Displayed | Download in RIS Format
| Other center views: | All 87 publications | 85 publications in selected types | All 78 journal articles |
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Azadniv M, Torres A, Boscia J, Speers DM, Frasier LM, Utell MJ, Frampton MW. Neutrophils in lung inflammation: which reactive oxygen species are being measured? Inhalation Toxicology 2001;13(6):485-495. |
R827354 (2004) R827354 (Final) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) R826781 (2001) R826781 (Final) |
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Beckett WS, Chalupa DF, Pauly-Brown A, Speers DM, Stewart JC, Frampton MW, Utell MJ, Huang L-S, Cox C, Zareba W, Oberdorster G. Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study. American Journal of Respiratory and Critical Care Medicine 2005;171(1):1129-1135. |
R827354 (2004) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Berger A, ZarebaW, Schneider A, Ruckerl R, Ibald-Mulli A, Cyrys J, Wichmann HE, Peters A. Runs of ventricular and supraventricular tachycardia triggered by air pollution in patients with coronary heart disease. Journal of Occupational and Environmental Medicine 2006;48(11):1149-1158. |
R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Cass GR, Hughes LA, Bahave P, Kleeman MJ, Allen JO, Salmon LG. The chemical composition of atmospheric ultrafine particles. The Philosophical Transactions of the Royal Society A: Mathematical, Physical, & Engineering Sciences 2000;358(1775):2581-2592. |
R827354 (2004) R827354 (Final) R827354C001 (1999) R827354C001 (2000) R827354C001 (Final) |
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Chalupa DC, Morrow PE, Oberdorster G, Utell MJ, Frampton MW. Ultrafine particle deposition in subjects with asthma. Environmental Health Perspectives 2004;112(8):879-882. |
R827354 (2004) R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Cyrys J, Heinrich J, Peters A, Kreyling W, Wichmann HE. Emission, immission und messung feiner und ultrafeiner partikel (Emission, immission and measurement of fine and ultrafine particles). Umweltmedizin Forschung Praxis 2002;7(2):67-77. |
R827354 (2004) R827354 (Final) R827354C002 (2001) R827354C002 (2002) R827354C002 (Final) R827354C003 (Final) |
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Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdorster G, Utell MJ, Frampton MW. Ultrafine particle deposition in humans during rest and exercise. Inhalation Toxicology 2003;15(6):539-552. |
R827354 (2004) R827354 (Final) R827354C003 (1999) R827354C003 (2000) R827354C003 (2001) R827354C003 (2002) R827354C003 (2003) R827354C003 (2004) R827354C003 (Final) R827354C004 (Final) R826781 (2001) R826781 (Final) |
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Dillner AM, Schauer JJ, Christensen WF, Cass GR. A quantitative method for clustering size distributions of elements. Atmospheric Environment 2005;39(8):1525-1537. |
R827354 (2004) R827354 (Final) R827354C001 (Final) |
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Elder AC, Gelein R, Oberdorster G, Finkelstein J, Notter R, Wang Z. Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. Experimental Lung Research 2004;30(2):105-120. |
R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) |
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Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein JN, Oberdorster G. Systemic interactions between inhaled ultrafine particles and endotoxin. Annals of Occupational Hygiene 2002;46(Suppl 1):231-234. |
R827354 (Final) R827354C003 (Final) R827354C004 (Final) R826784 (Final) |
not available |
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Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson D, Watts WF, Hopke P, Jeong C-H, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdorster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhalation Toxicology 2004;16(Suppl 1):41-53. |
R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R828046 (Final) |
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Elder ACP, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdorster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhalation Toxicology 2004;16(6-7):461-471. |
R827354 (Final) R827354C003 (Final) R827354C004 (2003) R827354C004 (Final) R827354C005 (Final) R826784 (Final) R828046 (Final) |
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Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdorster G. Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Experimental Lung Research 2005;31(6):527-546. |
R827354 (Final) R827354C004 (Final) R827354C005 (Final) |
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Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdorster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environmental Health Perspectives 2006;114(8):1172-1178. |
R827354 (Final) R827354C004 (Final) R827354C005 (Final) R832415C004 (2006) R832415C005 (2006) |
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Elder A, Couderc J-P, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdorster G. Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhalation Toxicology 2007;19(1):1-12. |
R827354 (Final) R827354C001 (Final) R827354C003 (Final) R827354C004 (Final) R832415C004 (2006) |
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Frampton MW. Systemic and cardiovascular effects of airway injury and inflammation: ultrafine particle exposure in humans. Environmental Health Perspectives 2001;109(S4):529-532. |
R827354 (Final) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) R826781 (2001) R826781 (Final) |
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Frampton MW, Stewart JC, Oberdorster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang L-S, Utell MJ. Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environmental Health Perspectives 2006;114(1):51-58. |
R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Frampton MW. Does inhalation of ultrafine particles cause pulmonary vascular effects in humans? Inhalation Toxicology 2007;19(Suppl 1):75-79. |
R827354 (Final) R827354C003 (Final) |
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Henneberger A, Zareba W, Ibald-Mulli A, Ruckerl R, Cyrys J, Couderc J-P, Mykins B, Woelke G, Wichmann H-E, Peters A. Repolarization changes induced by air pollution in ischemic heart disease patients. Environmental Health Perspectives 2005;113(4):440-446. |
R827354 (Final) R827354C002 (2003) R827354C002 (Final) |
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Hopke PK, Ito K, Mar T, Christiansen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stölzel M, Suh H, Paatero P, Thurston GD. PM source apportionment and health effects: 1. Intercomparison of source apportionment results. Journal of Exposure Science & Environmental Epidemiology 2006;16(3):275-286. |
R827354 (Final) R827354C001 (Final) R827353 (Final) R827353C017 (Final) R827355 (Final) R827355C008 (Final) |
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Ibald-Mulli A, Wichmann H-E, Kreyling W, Peters A. Epidemiological evidence on health effects of ultrafine particles. Journal of Aerosol Medicine 2002;15(2):189-201. |
R827354 (Final) R827354C002 (2001) R827354C002 (2003) R827354C002 (Final) |
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Ito K, Christiansen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Neas L, Hopke PK, Thurston GD. PM source apportionment and health effects: 2. An investigation of intermethod variability in associations between source-apportioned fine particle mass and daily mortality in Washington, DC. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):300-310. |
R827354 (Final) R827354C001 (Final) R827351 (Final) R827351C001 (Final) R827353 (Final) R827353C015 (Final) R827355 (Final) R827355C008 (Final) R827997 (Final) |
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Jeong C-H, Hopke PK, Chalupa D, Utell M. Characteristics of nucleation and growth events of ultrafine particles measured in Rochester, NY. Environmental Science & Technology 2004;38(7):1933-1940. |
R827354 (Final) R827354C001 (2003) R827354C001 (Final) R827354C003 (Final) |
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Jeong C-H, Lee D-W, Kim E, Hopke PK. Measurement of real-time PM2.5 mass, sulfate, and carbonaceous aerosols at the multiple monitoring sites. Atmospheric Environment 2004;38(31):5247-5256. |
R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
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Jeong C-H, Hopke PK, Kim E, Lee D-W. The comparison between thermal-optical transmittance elemental carbon and Aethalometer black carbon measured at multiple monitoring sites. Atmospheric Environment 2004;38(31):5193-5204. |
R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
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Jeong C-H, Evans GJ, Hopke PK, Chalupa D, Utell MJ. Influence of atmospheric dispersion and new particle formation events on ambient particle number concentration in Rochester, United States, and Toronto, Canada. Journal of the Air & Waste Management Association 2006;56(4):431-443. |
R827354 (Final) R827354C001 (Final) R827354C003 (Final) |
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Kim E, Larson TV, Hopke PK, Slaughter C, Sheppard LE, Claiborn C. Source identification of PM2.5 in an arid Northwest U.S. City by positive matrix factorization. Atmospheric Research 2003;66(4):291-305. |
R827354 (Final) R827354C001 (Final) R827355 (2004) R827355 (Final) R827355C008 (2002) R827355C008 (Final) R827355C009 (2003) R828678C010 (2003) R828678C010 (2004) R828678C010 (2005) R828678C010 (2006) R828678C010 (2007) |
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Kim E, Hopke PK, Larson TV, Covert DS. Analysis of ambient particle size distributions using Unmix and positive matrix factorization. Environmental Science & Technology 2004;38(1):202-209. |
R827354 (Final) R827354C001 (Final) R827354C002 (2004) R827355 (2004) R827355 (Final) R827355C004 (2003) R827355C008 (2002) R827355C008 (2003) R827355C008 (Final) |
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Kim E, Hopke PK, Larson TV, Maykut NN, Lewtas J. Factor analysis of Seattle fine particles. Aerosol Science and Technology 2004;38(7):724-738. |
R827354 (Final) R827354C001 (Final) R827355 (2004) R827355 (Final) R827355C004 (2003) R827355C008 (2003) R827355C008 (Final) |
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Kittelson DB, Watts WF, Johnson JP, Remerowki ML, Ische EE, Oberdorster G, Gelein RM, Elder A, Hopke PK, Kim E, Zhao W, Zhou L, Jeong C-H. On-road exposure to highway aerosols. 1. Aerosol and gas measurements. Inhalation Toxicology 2004;16(Suppl 1):31-39. |
R827354 (Final) R827354C001 (Final) R827354C004 (2003) R827354C004 (Final) |
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Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H, Oberdorster G, Ziesenis A. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. Journal of Environmental Science and Health. Part A 2002;65(20):1513-1530. |
R827354 (Final) R827354C004 (2001) R827354C004 (Final) |
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Lippmann M, Frampton M, Schwartz J, Dockery D, Schlesinger R, Koutrakis P, Froines J, Nel A, Finkelstein J, Godleski J, Kaufman J, Koenig J, Larson T, Luchtel D, Liu L-J S, Oberdorster G, Peters A, Sarnat J, Sioutas C, Suh H, Sullivan J, Utell M, Wichmann E, Zelikoff J. The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans. Environmental Health Perspectives 2003;111(8):1074-1092. |
R827354 (Final) R827351 (2002) R827351 (Final) R827352 (Final) R827352C002 (Final) R827352C014 (Final) R827353 (Final) R827353C006 (Final) R827353C015 (Final) R827355 (Final) |
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Mar TF, Ito K, Koenig JQ, Larson TV, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Neas L, Stolzel M, Paatero P, Hopke PK, Thurston GD. PM source apportionment and health effects. 3. Investigation of inter-method variations in associations between estimated source contributions of PM2.5 and daily mortality in Phoenix, AZ. Journal of Exposure Science & Environmental Epidemiology 2006;16(4):311-320. |
R827354 (Final) R827354C001 (Final) R827351 (Final) R827353 (Final) R827353C015 (Final) R827355 (Final) R827355C002 (Final) R827355C008 (Final) |
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Moffet R, Shields L, Berntsen J, Devlin R, Prather K. Characterization of an ambient coarse particle concentrator used for human exposure studies: aerosol size distributions, chemical composition, and concentration enrichment. Aerosol Science and Technology 2004;38(11):1123-1137. |
R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
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Oberdorster G. Pulmonary effects of inhaled ultrafine particles. International Archives of Occupational and Environmental Health 2001;74(1):1-8. |
R827354 (Final) R827354C004 (2000) R827354C004 (2001) R827354C004 (Final) R826784 (Final) |
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Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. Journal of Toxicology and Environmental Health-Part A 2002;65(20):1531-1543. |
R827354 (Final) R827354C004 (2001) R827354C004 (Final) R826784 (Final) |
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Oberdorster G, Utell MJ. Ultrafine particles in the urban air: to the respiratory tract—and beyond? Environmental Health Perspectives 2002;110(8):A440-A441. |
R827354 (Final) R827354C003 (Final) R827354C004 (Final) R826784 (Final) |
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Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. Translocation of inhaled ultrafine particles to the brain. Inhalation Toxicology 2004;16(6-7):437-445. |
R827354 (Final) R827354C004 (2003) R827354C004 (Final) |
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Oberdorster G, Oberdorster E, Oberdorster J. Invited Review: Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environmental Health Perspectives 2005;113(7):823-839. |
R827354 (Final) R827354C004 (Final) |
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Oberdorster G, Stone V, Donaldson K. Toxicology of nanoparticles: a historical perspective. Nanotoxicology 2007;1(1):2-25. |
R827354C001 (Final) R832415 (2007) R832415C004 (2006) |
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Ogulei D, Hopke PK, Chalupa DC, Utell MJ. Modeling source contributions to submicron particle number concentrations measured in Rochester, New York. Aerosol Science and Technology 2007;41(2):179-201. |
R827354 (Final) R827354C001 (Final) R827354C003 (Final) R831078 (Final) |
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Pekkanen J, Peters A, Hoek G, Tiittanen P, Brunekreef B, de Hartog J, Heinrich J, Ibald-Mulli A, Kreyling WG, Lanki T, Timonen KL, Vanninen E. Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease: the exposure and risk assessment for fine and ultrafine particles in ambient air (ULTRA) study. Circulation 2002;106(8):933-938. |
R827354 (Final) R827354C002 (2001) R827354C002 (2002) R827354C002 (2003) R827354C002 (Final) |
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Peters A, Heinrich J, Wichmann HE. Gesundheitliche wirkungen von feinstaub: epidemiologie der kurzzeiteffekte (Health impact of exposure to fine particles. Epidemiology of short-term effects). Umweltmedizin in Forschung und Praxis 2002;7(2):101-115. |
R827354 (Final) R827354C002 (2001) R827354C002 (2002) R827354C002 (2003) R827354C002 (Final) |
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Peters A, von Klot S, Heier M, Trentinaglia I, Hormann A, Wichmann HE, Lowel H. Exposure to traffic and the onset of myocardial infarction. New England Journal of Medicine 2004;351(17):1721-1730. |
R827354 (Final) R827354C002 (Final) |
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Peters A. Particulate matter and heart disease: Evidence from epidemiological studies. Toxicology and Applied Pharmacology 2005;207(Suppl 2):477-482. |
R827354 (Final) R827354C002 (Final) |
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Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdorster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang L-S, Utell MJ. Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhalation Toxicology 2004;16(Suppl 1):59-72. |
R827354 (Final) R827354C003 (2003) R827354C003 (Final) R827354C004 (Final) R826781 (Final) |
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Riesenfeld E, Chalupa D, Gibb FR, Oberdorster G, Gelein R, Morrow PE, Utell MJ, Frampton MW. Ultrafine particle concentrations in a hospital. Inhalation Toxicology 2000;12(Suppl 2):83-94. |
R827354 (Final) R827354C003 (2000) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) R827354C004 (2000) R827354C004 (Final) R826781 (2000) R826781 (2001) R826781 (Final) |
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Ruckerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, Heinrich J, Marder V, Frampton M, Wichmann HE, Peters A. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. American Journal of Respiratory and Critical Care Medicine 2006;173(4):432-441. |
R827354 (Final) R827354C002 (2003) R827354C002 (Final) R827354C003 (Final) R827354C004 (Final) |
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Ruckerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdorster G, Wichmann HE, Peters A. Ultrafine particles and platelet activation in patients with coronary heart disease – results from a prospective panel study. Particle & Fibre Toxicology 2007;4(22 January):1. |
R827354 (Final) |
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Silva V, Corson N, Elder A, Oberdorster G. The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (UFP). Toxicological Sciences 2005;85(2):983-989. |
R827354 (Final) R827354C004 (2003) R827354C004 (Final) |
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Singal M, Finkelstein JN. Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells. Experimental Lung Research 2005;31(6):581-597. |
R827354 (Final) R827354C005 (Final) |
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Singal M, Finkelstein JN. Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and nonparticulate stimuli. Inhalation Toxicology 2005;17(9):415-425. |
R827354 (Final) R827354C005 (Final) |
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Spencer MT, Shields LG, Sodeman DA, Toner SM, Prather KA. Comparison of oil and fuel particle chemical signatures with particle emissions from heavy and light duty vehicles. Atmospheric Environment 2006;40(27):5224-5235. |
R827354 (Final) R827354C001 (Final) |
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Spencer MT, Prather KA. Using ATOFMS to determine OC/EC mass fractions in particles. Aerosol Science and Technology 2006;40(8):585-594. |
R827354 (Final) R827354C001 (Final) R831083 (Final) |
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Spencer MT, Shields LG, Prather KA. Simultaneous measurement of the effective density and chemical composition of ambient aerosol particles. Environmental Science & Technology 2007;41(4):1303-1309. |
R827354 (Final) R827354C001 (Final) R831083 (Final) R832415C001 (2006) |
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Stolzel M, Breitner S, Cyrys J, Pitz M, Wolke G, Kreyling W, Heinrich J, Wichmann H-E, Peters A. Daily mortality and particulate matter in different size classes in Erfurt, Germany. Journal of Exposure Science and Environmental Epidemiology 2007;17(5):458-467. |
R827354 (Final) R827354C002 (Final) |
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Su Y, Sipin MF, Furutani H, Prather KA. Development and characterization of an aerosol time-of-flight mass spectrometer with increased detection efficiency. Analytical Chemistry 2004;76(3):712-719. |
R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
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Su Y, Sipin MF, Prather KA, Gelein RM, Lunts A, Oberdorster G. ATOFMS characterization of individual model aerosol particles used for exposure studies. Aerosol Science and Technology 2005;39(5):400-407. |
R827354 (Final) R827354C001 (2003) R827354C001 (Final) R827354C004 (Final) |
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Su Y, Sipin M, Spencer M, Qin X, Moffet R, Shields L, Prather K, Venkatachari P, Jeong C-H, Kim E, Hopke P, Gelein R, Utell M, Oberdorster G, Berntsen J, Devlin R, Chen L. Real-time characterization of the composition of individual particles emitted from ultrafine particle concentrators. Aerosol Science and Technology 2006;40(6):437-455. |
R827354 (Final) R827354C001 (Final) R827354C003 (Final) R827354C004 (Final) |
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Thurston GD, Ito K, Mar T, Christensen WF, Eatough DJ, Henry RC, Kim E, Laden F, Lall R, Larson TV, Liu H, Neas L, Pinto J, Stotzel M, Suh H, Hopke PK. Workgroup report: workshop on source apportionment of particulate matter health effects--Inter-Comparison of results and implications. Environmental Health Perspectives 2005;113(12):1768-1774. |
R827354 (Final) R827354C001 (Final) R827351 (Final) R827351C001 (Final) R827353 (Final) R827353C015 (Final) R827355 (Final) R827355C008 (Final) |
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Toner SM, Shields LG, Sodeman DA, Prather KA. Using mass spectral source signatures to apportion exhaust particles from gasoline and diesel powered vehicles in a freeway study using UF-ATOFMS. Atmospheric Environment 2008;42(3):568-581. |
R827354 (Final) R827354C001 (Final) |
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Utell MJ, Frampton MW. Acute health effects of ambient air pollution: the ultrafine particle hypothesis. Journal of Aerosol Medicine 2000;13(4):355-359. |
R827354 (Final) |
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Utell MJ, Frampton MW. Toxicologic methods: controlled human exposures. Environmental Health Perspectives 2000;108(Suppl 4):605-613. |
R827354 (Final) |
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Utell MJ, Frampton MW, Zareba W, Devlin RB, Cascio WE. Cardiovascular effects associated with air pollution: potential mechanisms and methods of testing. Inhalation Toxicology 2002;14(12):1231-1247. |
R827354 (Final) R827354C003 (2001) R827354C003 (2002) R827354C003 (Final) R826781 (2001) R826781 (Final) |
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Venkatachari P, Hopke PK, Grover BD, Eatough DJ. Measurement of particle-bound reactive oxygen species in rubidoux aerosols. Journal of Atmospheric Chemistry 2005;50(1):49-58. |
R827354 (Final) R827354C001 (2003) R827354C001 (Final) |
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Venkatachari P, Zhou L, Hopke P, Schwab J, Demerjian K, Weimer S, Hogrefe O, Felton D, Rattigan O. An intercomparison of measurement methods for carbonaceous aerosol in the ambient air in New York City. Aerosol Science and Technology 2006;40(10):788-795. |
R827354 (Final) R827354C001 (Final) |
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Venkatachari P, Zhou L, Hopke PK, Felton D, Rattigan OV, Schwab JJ, Demerjian KL. Spatial and temporal variability of black carbon in New York City. Journal of Geophysical Research 2006;111:D10S05, doi:10.1029/2005JD006314. |
R827354 (Final) R827354C001 (Final) |
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Venkatachari P, Hopke PK, Brune WH, Ren X, Lesher R, Mao J, Mitchell M. Characterization of wintertime reactive oxygen species concentrations in Flushing, New York. Aerosol Science and Technology 2007;41(2):97-111. |
R827354 (Final) R827354C001 (Final) |
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Venkatachari P, Hopke PK. Characterization of products formed in the reaction of ozone with α-pinene: case for organic peroxides. Journal of Environmental Monitoring 2008;10(8):966-974. |
R827354 (Final) R827354C001 (Final) |
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Venkatachari P, Hopke PK. Development and evaluation of a particle-bound reactive oxygen species generator. Journal of Aerosol Science 2008;39(2):168-174. |
R827354 (Final) R827354C001 (Final) |
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Veranth JM, Gelein R, Oberdorster G. Vaporization–condensation generation of ultrafine hydrocarbon particulate matter for inhalation toxicology studies. Aerosol Science and Technology 2003;37(7):603-609. |
R827354 (Final) R827354C004 (2001) R827354C004 (Final) |
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von Klot S, Peters A, Aalto P, Bellander T, Berglind N, D’Ippoliti D, Elosua R, Hormann A, Kulmala M, Lanki T, Lowel H, Pekkanen J, Picciotto S, Sunyer J, Forastiere F, Health Effects of Particles on Susceptible Subpopulations (HEAPSS) Study Group. Ambient air pollution is associated with increased risk of hospital cardiac readmissions of myocardial infarction survivors in five European cities. Circulation 2005;112(20):3073-3079. |
R827354 (Final) R827354C002 (Final) |
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Yue W, Schneider A, Stolzel M, Ruckerl R, Cyrys J, Pan X, Zareba W, Koenig W, Wichmann HE, Peters A. Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 2007;621(1-2):50-60. |
R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Yue W, Schneider A, Ruckerl R, Koenig W, Marder V, Wang S, Wichmann HE, Peters A, Zareba W. Relationship between electrocardiographic and biochemical variables in coronary artery disease. International Journal of Cardiology 2007;119(2):185-191. |
R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Zareba W, Nomura A, Couderc JP. Cardiovascular effects of air pollution: what to measure in ECG? Environmental Health Perspectives 2001;109(Suppl. 4):533-538. |
R827354 (Final) R827354C003 (Final) R827354C004 (Final) |
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Zhao W, Hopke PK, Qin X, Prather KA. Predicting bulk ambient aerosol compositions from ATOFMS data with ART-2a and multivariate analysis. Analytica Chimica Acta 2005;549(1-2):179-187. |
R827354 (Final) R827354C001 (Final) R831083 (Final) |
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Zhou L, Kim E, Hopke PK, Stanier C, Pandis SN. Mining airborne particulate size distribution data by positive matrix factorization. Journal of Geophysical Research 2005;110:D07S19, doi:10.1029/2004JD004707. |
R827354 (Final) R827354C001 (Final) |
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Zhou L, Hopke PK, Venkatachari P. Cluster analysis of single particle mass spectra at Flushing, NY. Analytica Chimica Acta 2006;555(1):47-56. |
R827354 (Final) R827354C001 (Final) |
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pollution prevention, atmosphere, particulates, metals, sensitive population, Air, Health, Scientific Discipline, Waste, Biochemistry, Children’s Health, Environmental Chemistry, Health Risk Assessment, Incineration/Combustion, Molecular Biology/Genetics, Risk Assessments, air toxics, particulate matter, tropospheric ozone, PM2.5, aerosol, aerosols, ambient air, ambient air monitoring, ambient air quality, ambient monitoring, animal model, cardiopulmonary, cardiopulmonary responses, cardiovascular disease, cardiovascular vulnerability, combustion engines, coronary artery disease, cytokine production, environmental health effects, epidemiology, fine particles, health effects, human exposure, human health, human health effects, inhalation toxicology, lead, lung, lung inflamation, metals, morbidity, mortality, particle exposure, particle size, particulate exposure, particulates, pathophysiological mechanisms, pulmonary, pulmonary disease, risk assessment, sensitive populations, stratospheric ozone, susceptible populations, ultrafine particles, urban air pollution,
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Air, Scientific Discipline, Waste, Health, RFA, Molecular Biology/Genetics, Risk Assessments, Health Risk Assessment, Incineration/Combustion, air toxics, Children's Health, Biochemistry, particulate matter, Environmental Chemistry, tropospheric ozone, aerosols, cardiopulmonary, epidemiology, risk assessment, susceptible populations, ultrafine particles, urban environment, aerosol, ambient air quality, cardiovascular disease, cardiovascular vulnerability, coronary artery disease, health effects, mortality, lung inflamation, epidemelogy, inhalation toxicology, ambient air, fine particles, lead, environmental health effects, cardiopulmonary responses, human health risk, cytokine production, particle exposure, human health effects, particulates, PM 2.5, PM2.5, sensitive populations, combustion engines, ambient monitoring, lung, metals, stratospheric ozone, ambient air monitoring, pathophysiological mechanisms, pulmonary, urban air pollution, human health, human exposure, morbidity, particle size, pulmonary disease, animal model
Relevant Websites:
http://www2.envmed.rochester.edu/envmed/PMC/
Progress and Final Reports:
Original Abstract
Final Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R827354C001 Characterization of the Chemical Composition of Atmospheric Ultrafine Particles
R827354C002 Inflammatory Responses and Cardiovascular Risk Factors in Susceptible Populations
R827354C003 Clinical Studies of Ultrafine Particle Exposure in Susceptible Human Subjects
R827354C004 Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events
R827354C005 Ultrafine Particle Cell Interactions: Molecular Mechanisms Leading to Altered Gene Expression
R827354C006 Development of an Electrodynamic Quadrupole Aerosol Concentrator
R827354C007 Kinetics of Clearance and Relocation of Insoluble Ultrafine Iridium Particles From the Rat Lung Epithelium to Extrapulmonary Organs and Tissues (Pilot Project)
R827354C008 Ultrafine Oil Aerosol Generation for Inhalation Studies