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CXCR4 inhibitor MSX-122 An orally bioavailable inhibitor of CXCR4 with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the GPCR (G protein-coupled receptor) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; it is also a co-receptor for HIV entry into T cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081025013912im_/http://www.cancer.gov/images/spacer.gif) | CXC chemokine receptor 4 inhibitor MSX-122 | | ![](https://webarchive.library.unt.edu/eot2008/20081025013912im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081025013912im_/http://www.cancer.gov/images/spacer.gif) | MSX-122 | | ![](https://webarchive.library.unt.edu/eot2008/20081025013912im_/http://www.cancer.gov/images/spacer.gif) |
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