Curriculum Vitae
Cellular, Tissue and Gene Therapies Advisory Committee
BIOGRAPHICAL SKETCH
| NAME | POSITION TITLE |
|---|---|
| Farshid Guilak, Ph.D. | Professor |
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
| INSTITUTION AND LOCATION | DEGREE | YEAR(s) | FIELD OF STUDY |
|---|---|---|---|
| Rensselaer Polytechnic Institute, Troy NY | B.S. | ---- | Biomedical Engineering |
| Rensselaer Polytechnic Institute, Troy NY | M.S. | ---- | Biomedical Engineering |
| Columbia University, New York NY | M.Phil. | ---- | Mechanical Engineering |
| Columbia University, New York NY | Ph.D. | ---- | Mechanical Engineering |
| Professional Experience | |
|---|---|
| 1986-91 | Frank E. Stinchfield Fellow in Orthopaedic Biomechanics, Columbia Univ., Advisor: Van C. Mow |
| 1991-94 | Assistant Professor of Orthopaedics, SUNY Stony Brook, Adjunct Asst. Prof. of Mech. Eng. |
| 1994-00 | Assistant Research Professor of Orthopaedic Surgery, Duke University Medical Center |
| 1994- | Assistant Professor of Biomedical Eng. and Mechanical Eng. & Materials Science, Duke Univ. |
| 1999- | Director of Research, Division of Orthopaedic Surgery |
| 2001- | Associate Professor of Surgery (with tenure) |
| 2002-4 | Co-Director, Center for Biomolecular and Tissue Engineering, Duke University |
| 2002- | Editor-in-Chief, North America, Journal of Biomechanics |
| 2004- | Professor of Surgery |
| 2006- | Laszlo Ormandy Endowed Professor of Orthopaedic Surgery |
Honors and Awards
Frank E. Stinchfield Fellowship in Orthopaedic Biomechanics, 1986-1991
Best Paper Award, American Society of Mechanical Engineers, Student Paper Competition, 1990
Young Investigator's Award, Orthopaedic Research Societies of USA, Japan, and Canada, 1991
Young Investigator's Award, World Congress on Medical Physics and Biomedical Engineering, 1991
New Investigator Recognition Award, Orthopaedic Research Society, 1994
Presidential Scholarship Award, Scanning Microscopy Society, 1997
FIRST Award, National Institutes of Health (NIAMS), 1997
George W. Thorn Award, The Whitaker Foundation, 1997
Invited Delegate, National Academy of Engineering meeting on “Frontiers of Engineering”, 1997
Kappa Delta Young Investigator Award, American Academy of Orthopaedic Surgeons, 1998
William Harris Award, Orthopaedic Research Society, 2000
Y.C. Fung Young Investigator Award, American Society of Mechanical Engineers, 2000
Richard Skalak Best Paper Award, American Society of Mechanical Engineers, 2004
Faculty of 1000, BiomedCentral, 2004
College of Fellows, American Institute for Medical and Biological Engineering, 2005
Marshall Urist Award for Excellent in Tissue Regeneration Research, Orthopaedic Research Society, 2006
Related Professional Service
Editorial Consultant’s Panel, J Biomech, 1999-02; Editorial Board, OA & Cart, 2001-present; Editorial Board, E-BIOMED, 2001-4; Editorial Board, DNA & Cell Biology, 2004-, Editorial Board, Current Rheumatology Reviews; Guest Editor, J Biomech, Special Issue on “Cell Mechanics”, 1/00; Guest Editor, J Biomech Eng, Special Issue on “Cell and Tissue Engineering”, 6/00.
Books
Cell Mechanics and Cellular Engineering. Eds. V.C. Mow, F. Guilak, R. Tran-Son-Tay, and R.M. Hochmuth, Springer Verlag, New York, 1994.
Functional Tissue Engineering. Eds: F. Guilak, D. Butler, D. Mooney, and S. Goldstein. Springer Verlag, NY, 2003.
Peer-Reviewed Journal Articles (selected)
Tognana, E., Chen, F., Padera, R.F., Leddy, H.A., Christensen, S.E., Guilak, F., Vunjak-Novakovic, and Freed, L.E. (2005): Adjacent tissues (cartilage, bone) affect the functional integration of engineered cartilage in vitro. Osteoarthritis & Cartilage, 13(2):129-138.
Alexopoulos, L.G., Williams, G.M., Upton, M.L., Setton, L.A., and Guilak, F. (2005): Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. Journal of Biomechanics, 38(3):509-17.
Alexopoulos, L.G., Setton, L.A., and Guilak, F. (2005): The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Acta Biomaterialia, 1(3):317-325.
Wang, D.W., Fermor, B., Gimble, J.M., Awad, H.A., and Guilak, F. (2005): The influence of oxygen on the proliferation and metabolism of adipose derived adult stem cells. Journal of Cell Physiology, 204(1):184-191.
Hewitt, J., Harrelson, J., Dailiana, Z., Guilak, F., and Fink, C. (2005): The effect of intermittent pneumatic compression on fracture healing. Journal of Orthopaedic Trauma, 19(6):371-6.
Baaijens, F.T.P., Trickey, W.R., Laursen, T.A., and Guilak, F. Large deformation finite element analysis of micropipette aspiration to determine the mechanical properties of the chondrocyte. Annals of Biomedical Engineering, 33(4):494-501.
Magnussen, R., Guilak, F., and Vail, T.P. (2005): Cartilage degeneration in post-collapse cases of osteonecrosis of the femoral head: Altered mechanical properties in tension, compression, and shear. Journal of Orthopaedic Research, 23:576-583.
Liu, S., Brown, T.A., Zhou, J. Xiao, Z.S., Awad, H.A., Guilak, F., and Quarles, L.D. (2005): Role of matrix extracellular phosphogylcoprotein in the pathogenesis of X-linked hypophosphatemia. Journal of the American Society of Nephrology, 16(6):1645-53..
Magnussen, R., Guilak, F., and Vail, T.P. (2005): Articular cartilage degeneration in early post-collapse cases of osteonecrosis of the femoral head. Journal of Bone and Joint Surgery (American), 87:1272-7.
Xiao, Z., Awad, H.A., Liu, S., Mahliios, J., Zhang, S., Guilak, F., Mayo, M.S., and Quarles, L.D. (2005): Selective Runx2-II deficiency leads to low turnover osteopenia in adult mice. Developmental Biology, 283(2):345-56.
Guilak, F., Alexopoulos, L.G., Haider, M.A., Ting-Beall, H.P. and Setton, L.A. (2005): Zonal uniformity in mechanical properties of the chondrocyte pericellular matrix: Micropipette aspiration of canine chondrons isolated by cartilage homogenization. Annals of Biomedical Engineering, 33(10):1312-1318.
Fermor, B., Weinberg, J.B., Pisetsky, D.S., and Guilak, F. (2005): The influence of oxygen tension on the induction of nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage. Osteoarthritis Cartilage, 13(10):935-941
Griffin , T.M. and Guilak, F. (2005): The role of mechanical loading in the onset and progression of osteoarthritis. Exercise and Sports Sciences Reviews, 33(4):195-200.
Piscoya, J.L., Fermor, B., Kraus, V.B., Stabler, T.V., and Guilak, F. (2005): The dose response relationship of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants. Osteoarthritis & Cartilage, 13(12):1092-1099.
Trickey, W.R., Baaijens, F.P.T., Laursen, T.A., Alexopoulos, L.G., and Guilak, F. (2006): Determination of the Poisson's ratio of the cell: Recovery properties of chondrocytes after release from complete micropipette aspiration. Journal of Biomechanics, 39(1):78-87.
Betre, H., Ong, S.R., Guilak, F., Chilkoti, A., Fermor, B., and Setton, L.A. (2006): Elastin-like polypeptides promote chondrocytic differentiation of human adipose derived adult stem cells in vitro. Biomaterials, 27(1):91-99.
Guilak, F., Lott, K.E., Awad, H.A., Hicok, K., Fermor, B., and Gimble, J.M. (2006): Clonal analysis of the differentiation potential of human adipose-derived adult stem cells. Journal of Cellular Physiology, 39(1):78-87.
Merryman, W.D., Youn, I., Lukoff, H.D., Krueger, P.M., Guilak, F., Hopkins, R.A., and Sacks, M.S. (2006): Correlating heart valve interstitial cell stiffness and transvalvular pressure: Implications for collagen biosynthesis. American Journal of Physiology-Heart and Circulatory Physiology, 290(1):H224-31.
Fetter, N.L., Leddy, H.A., Guilak, F., and Nunley, J.A. (2006): Composition and transport properties of human ankle and knee cartilage. Journal of Orthopaedic Research, 24(2):211-219.
Darling, E.M., Zauscher, S., and Guilak, F. Viscoelastic properties of zonal, articular chondrocytes measured by AFM and micropipette aspiration. Osteoarthritis & Cartilage, 14(6):571-579.
Haider, M.A., Schugart, R.C., Setton, L.A., and Guilak, F. (2006): A mechano-chemical model for the passive swelling response of an isolated chondron under osmotic loading. Biomechanics and Modeling in Mechanobiology, (2-3):160-71.
Upton , M.L., Guilak, F., Laursen, T.A., and Setton, L.A. (2006): Finite element modeling predictions of region-specific cell-matrix mechanics in the meniscus. Biomechanics and Modeling in Mechanobiology, (2-3):140-49.
Guilak, F., Alexopoulos, L.G., Upton, M.L., Youn, I., Choi, J.B., Cao, L., Setton, L.A., and Haider, M.A. (2006): The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Annals of the New York Academy of Sciences, 1068:498-512.
Qi, J., Fox, A.M., Alexopoulos, L.G., Chi, L., Bynum, D., Guilak, F., and Banes, A.J. (2006): IL-1 decreases the elastic modulus of human tenocytes. Journal of Applied Physiology, 101(1):189-95.
Estes, B.T., Wu, A.W., and Guilak, F. (2006): Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis & Rheumatism, 54(4):1222-12.
Pritchard, S., and Guilak, F. (2006): Interleukin-1 initiates calcium signaling and increases F-actin in isolated and in situ articular chondrocytes. Arthritis & Rheumatism, 54(7):2164-2174.
Leddy, H.A., Haider, M.A., and Guilak, F. (2006): Diffusional anisotropy of macromolecules in collagenous tissues measured by fluorescence imaging of continuous point photobleaching. Biophysical Journal, 91(1):311-6.
Youn, I., Choi, J.B., Cao, L., Setton, L.A., and Guilak, F. (2006): Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy. Osteoarthritis & Cartilage, 14(9):889-897.
Hu, K., Xu, L., Cao, L., Flahiff, C.M., Setton, L.A., Youn, I., Brussiau, J., Ho, K, Guilak, F., Olsen, B.R., and Li, Y. (2006): Pathogenesis of osteoarthritis-like changes in joints of type IX collagen-deficient mice. Arthritis & Rheumatism, 54(9):2891-290.
Upton , M.L., Hennerbichler, A., Fermor, B., Guilak, F., Weinberg, J.B., and Setton, L.A. (2006): Biaxial strain effects on cells from the inner and outer regions of the meniscus. Connective Tissue Research, 47(4):207-14.
Cao, L., Youn, I, Guilak, F., and Setton, L.A. Biphasic properties of mouse articular cartilage determined in a novel micro-indentation test. Journal of Biomechanical Engineering, 128(5):766-771.
Estes, B.T., Wu, A.W., Storms, R., and Guilak, F. (2006): Extended passaging, but not aldehyde dehydrogenase, increases the chondrocytic differentiation of human adipose-derived adult stem cells. Journal of Cellular Physiology, 209:987–995.
BIOGRAPHY
Farshid Guilak, Ph.D.
Dr. Guilak is Professor of Surgery and Director of Research for the Division of Orthopaedic Surgery at Duke University Medical Center. He also holds faculty appointments in the Department of Biomedical Engineering and the Department of Mechanical Engineering & Materials Science at Duke University. Dr. Guilak received bachelor’s and master’s degrees from Rensselaer Polytechnic Institute and a Ph.D. in Mechanical Engineering from Columbia University.
Dr. Guilak’s research has focused on the biomechanics of the musculoskeletal system, with special emphasis on the study of cellular mechanics and tissue engineering of articular cartilage. His laboratory has used a hierarchical approach to investigate the role of biomechanical factors in the onset and progression of joint disease, ranging from the cell and molecular level to that of the whole body. Dr. Guilak directs an NIH program project grant studying the role of obesity and inflammation in the pathogenesis of osteoarthritis. He also directs a post-doctoral NIH training grant focusing on Biomolecular and Tissue Engineering. Recently, he has been responsible for promoting the field of “Functional Tissue Engineering”, a new initiative that focuses on the role of biomechanical factors in engineered tissue repair and regeneration. His work in this area has focused on the regeneration of articular cartilage by combining novel 3D biomaterial structures with adipose-derived adult stem cells.
Dr. Guilak has co-authored over 100 peer-reviewed articles and 200 other scientific publications. He is the co-editor of two texts, “Cell Mechanics and Cellular Engineering”, and “Functional Tissue Engineering”, both published by Springer-Verlag. He is the editor-in-chief of the J Biomech and serves on the editorial boards of several journals, including Osteoarthritis & Cartilage, Current Rheumatology Reviews, and DNA & Cell Biology.