Introduction to the Prostate
Prostate Changes That Are Not Cancer
Prostate Cancer
Talking to Your Doctor
Types of Tests
For More Information
Introduction to the Prostate
You may be reading this booklet because you are having prostate
problems. The booklet can help answer your questions about
prostate changes that happen with age, such as:
- What are common prostate changes?
- How are these changes treated?
- What do I need to know about testing for prostate
changes, including cancer?
This booklet can give you basic information about common
prostate changes. If you are making decisions about prostate
cancer treatment, there are other resources available. See the For
More Information section.
The
prostate
is a small gland in men. It is part of the male
reproductive system.
The prostate is about
the size and shape of
a walnut. It sits low
in the
pelvis, below
the
bladder
and
just in front of the
rectum. The
prostate helps make
semen, the milky
fluid that carries
sperm
from the
testicles
through
the
penis
when a
man
ejaculates.
The prostate surrounds part of the
urethra, a tube that carries
urine
out of the bladder and through the penis.
The prostate gland surrounds the tube (urethra) that passes urine.
This can be a source of problems as a man ages because:
- The prostate tends to grow bigger with age and may
squeeze the urethra (see drawing) or
- A
tumor
can make the prostate bigger
These changes, or an infection, can cause problems passing urine.
Sometimes men in their 30s and 40s may begin to have these
urinary
symptoms and need medical attention. For others,
symptoms aren't noticed until much later in life. Be sure to tell
your doctor if you have any urinary symptoms.
Tell your doctor if you:
|
- Are passing urine more during the day
- Have an urgent need to pass urine
- Have less urine flow
- Feel burning when you pass urine
- Need to get up many times during the night to
pass urine
|
Growing older raises your risk of prostate problems. The three
most common prostate problems are:
One change does not lead to another. For example, having
prostatitis or an enlarged prostate does not raise your chance of
prostate cancer. It is also possible for you to have more than one
condition at the same time.
Most men have prostate changes that are not
cancer. |
Abnormal findings from any of these tests can help diagnose a
problem and suggest the next steps to take:
- DRE (digital rectal exam)--a test to feel the prostate
- PSA (prostate-specific antigen) test--a blood test
- Biopsy--a test to check for cancer
See the Types of Tests section.
Back to Top
Prostate Changes That Are Not Cancer
Prostatitis (pronounced "PRAH-stuh-TYE-tis") is an inflammation or
infection of the prostate gland. It affects at least half of all men at
some time in their lives. Having this condition does not increase
your risk of any other prostate disease.
Prostatitis Symptoms |
- Trouble passing urine or pain when passing urine
- A burning or stinging feeling when passing urine
- Strong, frequent urge to pass urine, even when there
is only a small amount of urine
- Chills and high fever
- Low back pain or body aches
- Pain low in the belly, groin, or behind the
scrotum
- Rectal pressure or pain
- Urethral discharge with bowel movements
-
Genital
and rectal throbbing
- Sexual problems and loss of sex drive
- Blocked urine
- Painful ejaculation (sexual climax)
|
Prostatitis is not contagious. It is not spread through sexual
contact. Your partner cannot catch this infection from you.
Several tests, such as DRE and a urine test, can be done to see if
you have prostatitis. Getting the right diagnosis of your exact type
of prostatitis is the key to getting the best treatment. Even if you
have no symptoms, you should follow your doctor's suggestion to
complete treatment.
There are four types of prostatitis:
-
Acute bacterial prostatitis
This infection comes on suddenly (acute) and is caused by
bacteria. Symptoms include severe chills and fever. There is often
blood in the urine. You must go to the doctor's office or
emergency room for treatment. It's the least common of the four
types, yet it's the easiest to diagnose and treat.
Treatment: | |
Most cases can be cured with a high dose of
antibiotics, taken for 7 to 14 days, and then lower
doses for several weeks. You may also need drugs to
help with pain or discomfort.
|
-
Chronic bacterial prostatitis
Also caused by bacteria, this condition doesn't come on suddenly,
but it can be bothersome. The only symptom you may have is
bladder infections that keep coming back. The cause may be a
defect in the prostate that lets bacteria collect in the urinary tract.
Treatment: | |
Antibiotic treatment over a longer period of time is
best for this type. Treatment lasts from 4 to 12 weeks.
This type of treatment clears up about 60 percent of
cases. Long-term, low-dose antibiotics may help
relieve symptoms in cases that won't clear up.
|
-
Chronic prostatitis or chronic pelvic pain
syndrome
This disorder is the most common but least understood form of
the disease. Found in men of any age from late teens to elderly, its
symptoms go away and then return without warning. There can
be pain or discomfort in the groin or bladder area.
Treatment: | |
There are several different treatments for this
problem, based on your symptoms. These include
antibiotics and other medicines, such as
alpha-blockers.
Alpha-blockers relax muscle tissue in the
prostate to make passing urine easier.
|
-
Asymptomatic inflammatory prostatitis
You usually don't have symptoms with this condition. It is often
found when your doctor is looking for other conditions like
infertility
or prostate cancer. If you have this problem, often
your PSA test (see The PSA Test) will show a higher number than
normal. It does not necessarily mean that you have cancer.
Treatment: | |
Men with this condition are usually given antibiotics
for 4 to 6 weeks, and then have another PSA test.
|
"Changes happen so slowly that you don't
even realize they're happening."
BPH stands for benign prostatic hyperplasia (pronounced "be-NINE
prah-STAT-ik HY-per-PLAY-zha").
Benign means "not cancer," and hyperplasia means too much
growth. The result is that the prostate becomes enlarged. BPH is
not linked to cancer and does not raise your chances of getting
prostate cancer--yet the symptoms for BPH and prostate cancer
can be similar.
BPH Symptoms |
BPH symptoms usually start after the age of 50.
They can include:
- Trouble starting a urine stream or making more than a
dribble
- Passing urine often, especially at night
- Feeling that the bladder has not fully emptied
- A strong or sudden urge to pass urine
- Weak or slow urine stream
- Stopping and starting again several times while passing urine
- Pushing or straining to begin passing urine
At its worst, BPH can lead to:
- A weak bladder
- Backflow of urine causing bladder or kidney infections
- Complete block in the flow of urine
- Kidney failure
|
BPH affects most men as they get older. It can lead to urinary
problems like those with prostatitis. By age 60, many men have
signs of BPH. By age 70, almost all men have some prostate
enlargement.
The prostate starts out about the size of a walnut. By the time a
man is 40, it may have grown slightly larger, to the size of an
apricot. By age 60, it may be the size of a lemon.
As a normal part of aging, the prostate enlarges and can press
against the bladder and the urethra. This can slow down or block
urine flow. Some men might find it hard to start a urine stream,
even though they feel the need to go. Once the urine stream has
started, it may be hard to stop. Other men may feel like they need
to pass urine all the time or are awakened during sleep with the
sudden need to pass urine.
Early BPH symptoms take many years to turn into bothersome
problems. These early symptoms are a cue to see your doctor.
Urine flow of normal (left) and enlarged prostate (right). In diagram on
the left, urine flows freely. On the right, urine flow is affected because of
the prostate pressing on the bladder and urethra.
About half the men with BPH eventually have symptoms that are
bothersome enough to need treatment. BPH cannot be cured, but
drugs or surgery can often relieve its symptoms. BPH symptoms
do not always grow worse.
There are three ways to manage BPH:
- Watchful waiting (regular follow-up with your doctor)
- Drug therapy
- Surgery
Talk with your doctor about the best choice for you. Your
symptoms may change over time, so be sure to tell your doctor
about any new changes.
Watchful waiting
Men with mild symptoms of BPH who do not find them
bothersome often choose this approach.
Watchful waiting means getting annual checkups. The checkups
can include DREs and other tests (see "Types of Tests"). Treatment is
started only if symptoms become too much of a problem.
If you choose to live with symptoms, these simple steps can help:
- Limit drinking in the evening, especially drinks with
alcohol or caffeine.
- Empty the bladder all the way when you pass urine.
- Use the restroom often. Don't wait for long periods
without passing urine.
"My doctor and I decide visit by visit about
how long I should stay on watchful waiting
for my BPH.
Some medications can make BPH symptoms worse, so talk with
your doctor or pharmacist about any medicines you are taking
such as:
- Over-the-counter cold and cough medicines (especially
antihistamines)
- Tranquilizers
-
Antidepressants
- Blood pressure medicine
Drug therapy
Millions of American men with mild-to-moderate BPH symptoms
have chosen prescription drugs over surgery since the early 1990s.
There are two main types of drugs used. One type relaxes muscles
near the prostate while the other type shrinks the prostate gland.
There is evidence that shows that taking both drugs together may
work best to keep BPH symptoms from getting worse.
Alpha-blockers
These drugs help relax muscles near the prostate to relieve pressure
and let urine flow more freely, but they don't shrink the size of the
prostate. For many men, the drug can improve urine flow and
reduce symptoms within days. Possible side effects include
dizziness, headache, and fatigue.
5 alpha-reductase inhibitor
This drug, known as
finasteride, shrinks the prostate. It relieves
symptoms by blocking an
enzyme
that acts on the male
hormone, testosterone, to boost organ growth. When the
enzyme
is blocked, growth slows down. This helps shrink the prostate,
reduce blockage, and limit the need for surgery.
Taking this drug for at least 6 months to 1 year can increase urine
flow and reduce your symptoms. It seems to work best for men
with very large prostates. You must continue to take the drug to
prevent symptoms from coming back.
This drug is also used to treat baldness in men. It can cause these
side effects in a small percentage of men:
- Decreased interest in sex
- Trouble getting or keeping an
erection
- Smaller amount of semen with ejaculation
It's important to note that taking this drug can lower your PSA test
levels. There is also evidence that finasteride lowers the risk of
getting prostate cancer, but whether it lowers the risk of dying
from prostate cancer is still unclear.
BPH Medications |
Category |
Activity |
Generic Name |
Brand Name |
Alpha-blockers |
Relax muscles
near prostate |
doxazosin
tamsulosin
terazosin
prazosin
|
Cardura
Flomax
Hytrin
Minipres
|
5 alphareductase
inhibitor |
Slows prostate growth, shrinks
prostate |
finasteride |
Proscar or
Propecia |
BPH surgery
The number of prostate surgeries has gone down over the years.
But operations for BPH are still one of the most common surgeries
for American men. Surgery is used when symptoms are severe or
drug therapy has not worked well.
Types of surgeries include:
-
TURP (transurethral resection of the prostate) is the most
common surgery for BPH. It accounts for 90 percent of all
BPH surgeries. It takes about 90 minutes. The doctor passes
an instrument through the urethra and trims away extra
prostate tissue. A
spinal block
is used to numb the area.
Tissue is sent to the laboratory to check for prostate cancer.
TURP generally avoids the two main dangers linked to other
prostate surgeries:
- Incontinence (not being able to hold in urine)
- Impotence (not being able to have an erection)
The recovery period for TURP is much shorter as well.
-
TUIP (transurethral incision of the prostate) is similar to
TURP. It is used on slightly enlarged prostate glands. The
surgeon places one or two small cuts in the prostate. This
relieves pressure without trimming away tissue. It has a low
risk of side effects. Like TURP, this treatment helps with urine
flow by widening the urethra.
-
TUNA (transurethral needle ablation) burns away excess
prostate tissue using radio waves. It helps with urine flow,
relieves symptoms, and may have fewer side effects than TURP.
Most men need a
catheter
to drain urine for a period of time
after the procedure.
-
TUMT (transurethral microwave thermotherapy) uses
microwaves sent through a catheter to destroy excess prostate
tissue. This can be an option for men who should not have
major surgery because they have other medical problems.
-
TUVP (transurethral electroevaporation of the prostate)
uses electrical current to vaporize prostate tissue.
-
Open prostatectomy means the surgeon removes the prostate
through a cut in the lower abdomen. This is done only in very
rare cases when obstruction is severe, the prostate is very large,
or other procedures can't be done. General or spinal
anesthesia is used and a catheter remains for 3 to 7 days after
the surgery. This surgery carries a higher risk of complications
than medical treatment. Tissue is sent to the laboratory to
check for prostate cancer.
Be sure to discuss options with your doctor and ask about the
potential short- and long-term benefits and risks with each
procedure. For a list of questions to ask, see
Checklist of Questions for Your Doctor.
Back to Top
Prostate Cancer
Prostate cancer means that cancer cells form in the tissues of the
prostate. It is the most common cancer in American men after
skin cancer.
Prostate cancer tends to grow slowly compared with most other
cancers. Cell changes may begin 10, 20, or 30 years before a
tumor gets big enough to cause symptoms. Eventually, cancer
cells may spread
(metastasize)
throughout the body. By the time
symptoms appear, the cancer may be more advanced.
By age 50, very few men have symptoms of prostate cancer, yet
some
precancerous
or cancerous cells are present. More than
half of all American men have some cancer in their prostate glands
by the age of 80.
Most of these cancers never pose a problem. They either give no
signs or symptoms or never become a serious threat to health.
A much smaller percentage of men are actually treated for prostate
cancer. Most men with prostate cancer do not die from this disease.
- About 16 percent of American men are diagnosed with
prostate cancer at some point in their lives.
- Eight percent have serious symptoms.
- Three percent die of the disease.
"When I first learned I might have a prostate
problem, I was afraid it was cancer."
Prostate cancer can sit quietly for years. That means most men
with the disease have no obvious symptoms. When symptoms
finally appear, they may be a lot like the symptoms of BPH.
Prostate Cancer Symptoms |
- Trouble passing urine
- Frequent urge to pass urine, especially at night
- Weak or interrupted urine stream
- Pain or burning when passing urine
- Blood in the urine or semen
- Painful ejaculation
- Nagging pain in the back, hips, or pelvis
|
Prostate cancer can spread to the
lymph nodes
of the pelvis.
Or it may spread throughout the body. It tends to spread to the
bones. So bone pain, especially in the back, can be another
symptom.
There are some risk factors linked to prostate cancer. A risk factor
is something that can raise your chances of having a problem or
disease. Having one or more risk factors doesn't mean that you
will get prostate cancer. It just means that your risk of disease is
greater.
- Age. Being 50 or older increases risk of prostate cancer.
- Race. African-American men are at highest risk of prostate
cancer--it tends to start at younger ages and grows faster than
in men of other races. After African-American men, it is most
common among white men, followed by Hispanic and Native
American men. Asian-American men have the lowest rates of
prostate cancer. Aside from race, all men can have other
prostate cancer risk factors (aging, family history, and diet).
See the
For More Information section to request the booklet
about African-American men and prostate cancer screening.
- Family history. Prostate cancer risk is 2 to 3 times higher for
men whose fathers or brothers have had the disease. For
example, risk is about 10 times higher for a man who has 3
immediate family members with prostate cancer. The younger
a man is when he has prostate cancer, the greater the risk for
his male family members. Prostate cancer risk also appears to
be slightly higher for men whose mothers or sisters have had
breast cancer.
- Diet. The risk of prostate cancer seems to be higher for men
eating high-fat diets with few fruits and vegetables.
National research studies are looking at how prostate cancer can be
prevented. There is some proof that the drug finasteride lowers
your risk of getting prostate cancer, but whether it decreases the
risk of dying of prostate cancer is still unclear.
To find out more, see the
For More Information section.
Prostate Cancer Screening |
Screening means testing for cancer before you have any
symptoms. A screening test can often help find cancer at an
early stage. When found early, cancer is less likely to have
spread and may be easier to treat. By the time symptoms
appear, the cancer may have started to spread. Remember,
even if your doctor suggests prostate cancer screening, this
doesn't necessarily mean that you have cancer.
Screening tests are most useful when they have been proven to
find cancer early and lower a person's chance of dying from
cancer. For prostate cancer, doctors don't yet know these
answers and more research is being done.
-
Large research studies, with thousands of men, are going on
now to study prostate cancer screening. The National
Cancer Institute is studying the combination of PSA testing
and DRE as a way to get more accurate results.
-
Some cancers never cause symptoms or become lifethreatening.
If they are found by a screening test, the
cancer may then be treated. For prostate cancer in its early
stages, it isn't known whether treatment would help you live
longer than if no treatment were given when a screening
test detects prostate cancer.
Talk with your doctor about your risk of prostate
cancer and your need for screening tests.
|
Back to Top
Talking to Your Doctor
Different kinds of doctors and other health care professionals
manage prostate health. They can help you find the best care,
answer your questions, and address your concerns. These health
care professionals include:
- Family doctors and internists
- Physician assistants (PAs) and nurse practitioners (NPs)
-
Urologists, who are experts in diseases of the male
reproductive and urinary tract systems
- Urologic oncologists, who are experts in treating cancers of the
male urinary and reproductive systems such as prostate cancer
- Radiation oncologists, who use radiation therapy to kill cancer
cells
- Medical oncologists, who treat cancers with medications such
as hormone treatments and chemotherapy
-
Pathologists, who are doctors who find diseases by studying
cells and tissues under a microscope
View these professionals as your partners--expert advisors and
helpers in your health care. Talking openly with your doctors can
help you learn more about your prostate changes and the tests to
expect.
Back to Top
Types of Tests
These types of tests are most often used to check the prostate:
This first step lets your doctor hear and understand the "story" of
your prostate concerns. You'll be asked about whether you have
symptoms, how long you've had them, and how much they affect
your lifestyle. Your health history also includes any risk factors,
pain, fever, or trouble passing urine. You may be asked to give a
urine sample for testing.
DRE is the standard way to check the prostate. With a gloved and
lubricated finger, your doctor feels the prostate from the rectum.
The test lasts about 10-15 seconds.
This exam checks for:
- The size, firmness, and texture of the prostate
- Any hard areas, lumps, or growth spreading beyond the
prostate
- Any pain caused by touching or pressing the prostate
The DRE allows the doctor to feel only one side of the prostate.
A PSA test is another way to help your doctor check your prostate.
PSA is a protein made by normal cells and prostate cancer cells. It
is found in the blood and can be measured with a blood test. PSA
tests are often used to follow men after prostate cancer treatment.
PSA testing is still being studied to see if finding cancer early
lowers the risk of dying from prostate cancer.
PSA levels can rise if a man has prostate cancer, but a high PSA is
not proof of cancer. Other things can also make PSA levels go up.
These may give a
false positive
test result. These include having
BPH or prostatitis, or if the prostate gland is disturbed in any way
(riding a bicycle or motorcycle, a DRE, orgasm within the past 24
hours, and prostate biopsy or surgery can disturb the prostate).
Also, some prostate glands naturally produce more PSA than
others. PSA levels go up with age. African-American men tend to
have higher PSA levels in general than men of other races.
Researchers are trying to find more answers about:
- The PSA test's ability to tell cancer from benign prostate
problems
- The best thing to do if a man has a high PSA level
For now, men and their doctors use PSA readings over time as a
guide to see if more follow-up is needed.
PSA levels are measured in terms of units per volume of fluid
tested. Doctors often use a score of 4
nanograms (ng)
or higher
as the trigger for further tests, such as a prostate biopsy.
Your doctor may monitor your PSA velocity, which means looking
at the rate of change in your PSA levels over time. Rapid increases
in PSA readings can suggest cancer. If you have a mildly elevated
PSA, you and your doctor may choose to check PSA levels on a
scheduled basis and watch for any change in the PSA velocity.
If your symptoms or test results suggest cancer, your doctor will
refer you to a specialist (a urologist) for a prostate biopsy. A
biopsy is usually done in the doctor's office.
For a biopsy, small tissue samples are taken directly from the
prostate. Your doctor will take samples from several areas of the
prostate gland. This can help lower the chance of missing any
areas of the gland that may have cancer cells. Like other cancers,
doctors can only diagnose prostate cancer by looking at tissue
under a microscope.
Most men who have biopsies after routine exams do not have cancer.
"There is no magic PSA level below which a man can be assured of
having no risk of prostate cancer nor above which a biopsy should
automatically be performed. A man's decision to have a prostate
biopsy requires a thoughtful discussion with his physician,
considering not only the PSA level, but also his other risk factors,
his overall health status, and how he perceives the risks and
benefits of early detection."
--Dr. Howard Parnes, Chief of the Prostate and Urologic Cancer Research Group,
Division of Cancer Prevention, National Cancer Institute
|
A test that can help your doctor decide if you need a repeat biopsy
is called
free PSA. This test is used for men who have higher PSA
values. The test looks at a form of PSA in the blood. Free PSA is
linked to BPH but not cancer.
Free PSA is figured as a percentage of the total PSA:
- If both total PSA and free PSA are higher than normal, this
suggests BPH rather than cancer.
- If regular PSA is high but free PSA is not, cancer is more
likely. More testing should be done.
Free PSA may help tell what kind of prostate problem you have. It
can be a guide for you and your doctor to choose the right
treatment. You and your doctor should talk about your personal
risk and free PSA results. Then you can decide together whether to
have follow-up biopsies and, if so, how often.
A positive biopsy means prostate cancer is present. A pathologist
will check your biopsy sample for cancer cells and will give a
Gleason score. The Gleason score ranges from 2 to 10 and
describes how likely it is that a tumor will spread. The lower the
number, the less likely the tumor is aggressive and may spread.
Treatment options depend on the stage (or extent) of the cancer
(stages range from 1 to 4), Gleason score, PSA level, and your age
and general health. These items will be available from your doctor
and are listed on your pathology report.
Reaching a decision about treatment of your prostate cancer is a
complex process. Many men find it helpful to talk with their
doctors, family, friends, and other men who have faced similar
decisions. There are many organizations that can provide more
information and support to you, your partner, and family.
"While it's important to make your own decision
about cancer screening, everybody should
consider getting a second opinion before
getting something like a biopsy."
It is a good idea to get a copy of your pathology report
from your doctor and carry it with you as you talk with
your health care providers.
Checklist of Questions for Your Doctor |
- What type of prostate problem do I have?
- Is more testing needed and what will it tell me?
- If I decide on watchful waiting, what changes in my
symptoms should I look for and how often should I
be tested?
- What type of treatment do you recommend for my prostate
problem?
- For men like me, has this treatment worked?
- How soon would I need to start treatment and how long
would it last?
- Do I need medicine and how long would I need to take it
before seeing improvement in my symptoms?
- What are the side effects of the medicine?
- Are there other medicines that could interfere with this
medication?
- If I need surgery, what are the benefits and risks?
- Would I have any side effects from surgery that could affect
my quality of life?
- Are these side effects temporary or permanent?
- How long is recovery time after surgery?
- Will I be able to fully return to normal?
- How will this affect my sex life?
- How often should I visit the doctor to monitor my condition?
|
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For More Information
National Cancer Institute
You can find out more from these free NCI services.
Cancer Information Service (CIS)
Toll-free ................1-800-4-CANCER (1-800-422-6237)
TTY ........................1-800-332-8615
NCI Online ............www.cancer.gov
Chat Online ..........www.cancer.gov and click on
"Need Help?"
Free booklets that are available include:
Other Federal Resources
Centers for Disease Control and Prevention
Toll-free ................1-888-842-6355
FAX ........................1-770-488-4760
E-mail ....................cancerinfo@cdc.gov
Online....................www.cdc.gov/cancer/prostate/
Free booklets that are available include:
- Prostate Cancer Screening: A Decision Guide
- Prostate Cancer Screening: A Decision Guide for African Americans
Medicare
For more information about Medicare benefits, contact:
Toll-free ................1-800-MEDICARE (1-800-633-4227)
Online....................www.medicare.gov
National Kidney and Urologic Diseases Information
Clearinghouse
Toll-free ................1-800-891-5390
Online....................www.niddk.nih.gov
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|