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human anti-alpha-v integrin monoclonal antibody A pan alpha-v human monoclonal antibody that recognizes alpha-v beta-1, alpha-v beta-3, alpha-v beta-5, and alpha-v beta-6 integrins with antiangiogenic and antitumor activities. Human anti-alpha-v integrin monoclonal antibody competitively binds to and blocks both alpha-v beta-3 and alpha-v beta-5 integrins, resulting in inhibition of integrin-mediated tumor angiogenesis and tumor growth.
Integrins facilitate
the adhesion of stimulated endothelial cells to the extracellular matrix (ECM); trigger the secretion of ECM-rearranging proteases; and propagate
signaling events that promote the survival and differentiation of
cells in newly formed vasculature. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code name: | | CNTO 95 | | |
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