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ixabepilone![Patient Information Patient Information](https://webarchive.library.unt.edu/eot2008/20081006045940im_/http://www.nci.nih.gov/images/btn-patient-info.gif) An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081006045940im_/http://www.nci.nih.gov/images/spacer.gif) | Azaepothilone B epothilone B lactam Epothilone-B BMS 247550 | | ![](https://webarchive.library.unt.edu/eot2008/20081006045940im_/http://www.nci.nih.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081006045940im_/http://www.nci.nih.gov/images/spacer.gif) | Ixempra | | ![](https://webarchive.library.unt.edu/eot2008/20081006045940im_/http://www.nci.nih.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081006045940im_/http://www.nci.nih.gov/images/spacer.gif) | BMS-247550 | | ![](https://webarchive.library.unt.edu/eot2008/20081006045940im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081006045940im_/http://www.nci.nih.gov/images/spacer.gif) | (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione | | ![](https://webarchive.library.unt.edu/eot2008/20081006045940im_/http://www.nci.nih.gov/images/spacer.gif) |
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