![](https://webarchive.library.unt.edu/eot2008/20081006054455im_/http://www.nci.nih.gov/images/spacer.gif) |
|
![](https://webarchive.library.unt.edu/eot2008/20081006054455im_/http://www.nci.nih.gov/images/spacer.gif)
selective androgen receptor modulator MDV3100 An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, selective androgen receptor modulator MDV3100 inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20081006054455im_/http://www.nci.nih.gov/images/spacer.gif)
Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081006054455im_/http://www.nci.nih.gov/images/spacer.gif) | MDV3100 | | ![](https://webarchive.library.unt.edu/eot2008/20081006054455im_/http://www.nci.nih.gov/images/spacer.gif) |
![](https://webarchive.library.unt.edu/eot2008/20081006054455im_/http://www.nci.nih.gov/images/spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20081006054455im_/http://www.nci.nih.gov/images/gray_spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20081006054455im_/http://www.nci.nih.gov/images/spacer.gif)
|
![](https://webarchive.library.unt.edu/eot2008/20081006054455im_/http://www.nci.nih.gov/images/spacer.gif) |