![](https://webarchive.library.unt.edu/eot2008/20081006045743im_/http://www.nci.nih.gov/images/spacer.gif) |
|
![](https://webarchive.library.unt.edu/eot2008/20081006045743im_/http://www.nci.nih.gov/images/spacer.gif)
indium In 111-CMD-193 A radiolabeled antibody-targeted antineoplastic antibiotic consisting of the enediyne antibiotic calicheamicin conjugated with anti-Lewis Y antibody and labeled with indium In 111. In 111 CMD-193 binds to Lewis Y antigen-expressing tumor cells via its antibody moiety and is internalized; subsequently, the calicheamicin moiety binds to the minor groove of tumor cell DNA, causing double-strand DNA breaks, the inhibition of DNA synthesis, and apoptosis. The indium In 111 radiolabel allows the detection of CMD-193 distribution and tumor localization using gamma scintigraphy. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20081006045743im_/http://www.nci.nih.gov/images/spacer.gif)
Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081006045743im_/http://www.nci.nih.gov/images/spacer.gif) | In 111 CMD-193 | | ![](https://webarchive.library.unt.edu/eot2008/20081006045743im_/http://www.nci.nih.gov/images/spacer.gif) |
![](https://webarchive.library.unt.edu/eot2008/20081006045743im_/http://www.nci.nih.gov/images/spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20081006045743im_/http://www.nci.nih.gov/images/gray_spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20081006045743im_/http://www.nci.nih.gov/images/spacer.gif)
|
![](https://webarchive.library.unt.edu/eot2008/20081006045743im_/http://www.nci.nih.gov/images/spacer.gif) |