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Vitamin Ks Place in a
Healthy Lifestyle
Nutritionists Kyla Shea (left) and Sarah Booth perform a DXA
scan on a volunteer to measure bone mineral density as part of the vitamin K
supplement study.
(D843-1)
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At this time, the goal for average daily vitamin K intake is 90 micrograms
for women and 120 micrograms for men. But only 27 percent of people in the
United States consume that amount, according to a food consumption survey
analysis from the Beltsville Maryland Human Nutrition Research Center (BHNRC),
part of the Agricultural
Research Service.
To provide the data for that analysis, researchers with the ARS-funded
Vitamin K Laboratory determined the amounts of three major types of vitamin K
in hundreds of foods. The laboratory is part of the Jean Mayer USDA Human
Nutrition Research Center on Aging at Tufts University, in Boston
Massachusetts. Through a collaboration, those data are available via BHNRCs
Nutrient Data Laboratory website. The collaboration is part of the National
Food and Nutrient Analysis Program, described in the story on
page 6
of this issue.
Sarah Booth, director of the Vitamin K Laboratory, and colleagues are also
using new methods to assess individuals' vitamin K blood plasma
concentrationsand associations between that status and chronic diseases.
For example, they have reported that higher blood levels of
phylloquinonethe main form of vitamin Kwere associated with a lower
risk of osteoarthritis (OA) in the hands and knees. OA involves the breakdown
of cartilage and bones, which causes pain and stiffness.
This study is particularly significant because low dietary intakes of
vitamin K are known to be associated with bone loss in the elderly, says
Booth. The study appeared in the April 2006 issue of Arthritis &
Rheumatism.
Vitamin K is also essential to blood clotting and cellular growth. Other
research conducted by Booth and colleagues raises new questions about the role
of inadequate vitamin K intake and the progression of arterial calcification,
or hardening of the arteries.
Newly discovered vitamin K-dependent proteins, such as matrix gla protein,
or MGP, are providing clues as to the mechanisms behind these associations. MGP
requires vitamin K to function. It is a binding protein that has been shown by
other researchers to play a key role in inhibiting calcification in cartilage
and in arterial vessels.
"Vitamin K intake may be a marker of a healthy diet because it is found
mainly in green, leafy vegetables and certain plant oils," says Booth.
"This could explain associations between low vitamin K intake and risk for
heart disease."
The laboratory's researchers recently completed a 3-year study in which 452
male and female volunteers, aged 60 to 80, were either supplemented with
adequate vitamin K or given a placebo. The data is being analyzed to see
whether there were changes in bone density or age-related vascular
calcification in the participants who received the vitamin K.By Rosalie Marion
Bliss, Agricultural Research Service Information Staff.
This research is part of Human Nutrition, an ARS national program (#107)
described on the World Wide Web at www.nps.ars.usda.gov.
Sarah L. Booth is with the
USDA-ARS Vitamin K Research Program, Jean
Mayer Human Nutrition Research Center on Aging at Tufts University, 711
Washington St., Boston, MA 02111-1524; phone (617) 556-3231, fax (617)
556-3149.
"Vitamin K's Place in a Healthy Lifestyle"
was published in the August 2007
issue of Agricultural Research magazine.
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