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5-hydroxytryptophan An aromatic amino acid with antidepressant activity. In vivo, 5-hydroxytryptophan (5-HTP) is converted into 5-hydroxytryptamine (5-HT or serotonin) as well as other neurotransmitters. 5-HTP may exert its antidepressant activity via conversion to serotonin or directly by binding to serotonin (5-HT) receptors within the central nervous system (CNS). Endogenous 5-HTP is produced from the essential amino acid L-tryptophan. Exogenous therapeutic 5-HTP is isolated from the seeds of the African plant Griffonia simplicifolia. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081005061705im_/http://www.nci.nih.gov/images/spacer.gif) | Oxitriptan | | ![](https://webarchive.library.unt.edu/eot2008/20081005061705im_/http://www.nci.nih.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081005061705im_/http://www.nci.nih.gov/images/spacer.gif) | 5-HTP | | ![](https://webarchive.library.unt.edu/eot2008/20081005061705im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081005061705im_/http://www.nci.nih.gov/images/spacer.gif) | 2-Amino-3-(5-hydroxy-1-H-indol-3-yl)propionic Acid | | ![](https://webarchive.library.unt.edu/eot2008/20081005061705im_/http://www.nci.nih.gov/images/spacer.gif) |
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