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Susan Zunino
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Susan Zunino

Research Molecular Biologist

Ph.D., Cell and Molecular Biology

Program in the School of Medicine

 

University of Nevada, Reno

 

Office:     430 West Health Sciences Dr.

                 University of California

                 Davis, CA 95616

             

Phone:     (530) 752-5156

 

Fax:         (530) 752-5271

 

 

 

 

 

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Page Summary:

 

 

 Biography

 

Research Interests

 

Research Accomplishments

 

Current Research Objectives

 

 

 

 

Biography

 

     Susan J. Zunino, Ph.D. is a research molecular biologist for studies on micronutrients and immune function at the USDA-ARS-Western Human Nutrition Research Center.  Dr. Zunino received her Ph.D. in cellular and molecular biology at the University of Nevada, Reno in 1989, and continued with postdoctoral research at the University of Texas Southwestern Medical Center.  In 1995, Dr. Zunino held an Assistant Professor position in the Department of Genetics at the University of Erlangen-Nuremberg in Germany, where she initiated a research program to examine antioxidant phytochemicals as novel chemopreventive agents against leukemia.  In July 2003, Dr. Zunino joined the USDA-ARS-Western Human Nutrition Research Center in Davis, CA, where she investigates the anti-leukemia and anti-inflammatory activities of antioxidant phytochemicals found in fruits, vegetables, spices, and herbs.  Current projects include dietary interventions using mouse models for leukemia and inflammatory autoimmune diseases, as well as human volunteers for inflammation associated with obesity.  Dr. Zunino serves as an Adjunct Associate Professor in the Department of Nutrition, University of California, Davis.  She is a member of the Scientific Advisory Committee for the California Strawberry Commission and the grant review panel of the American Heart Association Western Consortium.  She is a member of the American Association of Immunologists (AAI), American Association for Cancer Research (AACR), and the American Society for Nutrition.

 

 

Research Interests

 

     My research goals are to understand how antioxidant phytochemicals from fruits, vegetables, herbs, and spices regulate growth and function of normal and abnormal immune cells, and how they modify inflammatory reactions.  Cell culture, mouse models, and human volunteers are used to investigate the mechanisms of action of dietary phytochemicals.  Individual phytochemicals and whole foods are evaluated for their anti-cancer and anti-inflammatory activities.  Specific interests are the roles these phytochemicals may play in preventing leukemia growth and modulating autoimmune inflammatory diseases.  These studies will also aid in defining appropriate dietary intake levels of foods containing high concentrations of antioxidants that would contribute to the production of a healthy immune system in humans.

 

 

Research Accomplishments

 

·         Found that several phytochemicals such as resveratrol from grapes and carnosol from rosemary effectively killed acute leukemia cells, but had little toxicity to normal blood cells.

·         Discovered that phytochemicals kill acute leukemia cells by disrupting mitochondrial function and causing oxidative stress in the leukemic cells.

·         Showed that parthenolide from the herb feverfew was particulary potent in killing acute leukemia cells in a cell culture model.

·         Found that several phytochemical components isolated from strawberries (quercetin, kaempferol, ellagic acid) were effective in killing leukemia cells.

·         Found that feeding nonobese diabetic mice food containing 1% grape powder (which contains high levels of antioxidants) delayed the progression of type I diabetes and increased survival of the mice compared to mice receiving regular food.

 

 

Current Research Objectives

 

·         To determine anti-leukemia activities of polyphenolic antioxidants and the cellular and molecular mechanisms of cell death.

·         To evaluate the anti-inflammatory activity of antioxidant-rich diets and whether they are useful for preventing or managing inflammatory autoimmune diseases, such as type I diabetes, lupus, and multiple sclerosis. 

·         To assess the role of antioxidant-rich diets in reducing the morbidity and mortality of obese individuals who have a higher risk for developing cardiovascular disease, diabetes, and hypertension.


   
 
Last Modified: 07/20/2007
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