[Federal Register: May 1, 1998 (Volume 63, Number 84)]
[Notices]               
[Page 24165-24166]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr01my98-54]

-----------------------------------------------------------------------

DEPARTMENT OF DEFENSE

Department of the Army

 
Availability of Non-Exclusive, Exclusive, or Partially Exclusive 
Licensing of U.S. Patent Application SN 09/035,910 Concerning Improved 
Method for Purifying Cholera Toxin

AGENCY: U.S. Army Medical Research and Materiel Command, DoD.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: In accordance with 37 CFR 404.6, announcement is made of the 
availability of U.S. Patent Application SN 09/035,910 entitled 
``Improved

[[Page 24166]]

Method for Purifying Cholera Toxin.'' This patent has been assigned to 
the United States Government as represented by the Secretary of the 
Army.

ADDRESSES: Commander, U.S. Army Medical Research and Materiel Command, 
Command Judge Advocate, MCMR-JA, 504 Scott Street, Fort Detrick, MD 
21702-5012.

FOR FURTHER INFORMATION CONTACT:
Mr. Charles Harris, Patent Attorney, 301-619-7807, Fax 301-619-5034.

SUPPLEMENTARY INFORMATION: A new affinity purification method has been 
developed that can be used to purify cholera toxin (CT) and the B 
subunit of CT. In addition to purifying the native CT, it can be used 
to purify chemical conjugates or genetically engineered fusion proteins 
composed of CTB. This purification procedure is highly selective, since 
it can be used to purify CT but not the closely related heat-labile 
enterotoxin of Escherichia coli. This procedure is extremely fast and 
simple to perform, resulting in an extremely pure preparation. The 
affinity matrix is available commercially and can be used repeatedly 
without loss of affinity or resolution.
Mary V. Yonts,
Alternate Army Federal Register Liaison Officer.
[FR Doc. 98-11590 Filed 4-30-98; 8:45 am]
BILLING CODE 3710-08-M