[Federal Register: March 8, 2002 (Volume 67, Number 46)]
[Notices]
[Page 10734-10735]
From the Federal Register Online via GPO Access [wais.access.gpo.gov]
[DOCID:fr08mr02-80]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Toxicology Program (NTP); National Institute of
Environmental Health Science (NIEHS)
The NTP Center for the Evaluation of Risks to Human Reproduction
(CERHR) Announces the Availability of and Requests Public Comments on
Two Expert Panel Reports: Expert Panel Report on the Developmental and
Reproductive Toxicity of 1-Bromopropane and Expert Panel Report on the
Developmental and Reproductive Toxicity of 2-Bromopropane.
Summary
Notice is hereby given of the availability of the Expert Panel
Report on the Developmental and Reproductive Toxicity of 1-Bromopropane
and the Expert Panel Report on the
[[Page 10735]]
Developmental and Reproductive Toxicity of 2-Bromopropane. These
reports include the summaries and conclusions of the expert panel's
evaluation of the scientific data for potential reproductive and/or
developmental hazards associated with exposure to 1-bromopropane and 2-
bromopropane. The CERHR held this expert panel meeting in December
2001. CERHR is seeking public comment on these reports and additional
information about recent, relevant toxicology studies or human
exposure.
Availability of Reports
Copies of the two expert panel reports are available electronically
on the CERHR Web site (http://cerhr.niehs.nih.gov). To receive a
printed copy of either report, please contact the CERHR at P.O. Box
12233, MD EC-32, Research Triangle Park, NC 27709 (mail), (919) 541-
3455 (phone), (919) 316-4511 (fax), or shelby@niehs.nih.gov (email).
Request for Public Comments
The CERHR invites public comments on the expert panel reports and
input regarding any recent, relevant toxicology data or human exposure
information for either chemical. The CERHR asks that all comments and
other information be submitted to the CERHR at the address above by
[Please insert date 60 days from publication of this notice].
All public comments on these reports received by this date will be
reviewed and included in the final NTP-CERHR reports prepared by NTP
staff. The NTP-CERHR report for each chemical will include the expert
panel report, public comments received on the report, and the NTP
brief. The NTP brief will provide the NTP's interpretation of the
potential for adverse reproductive and/or developmental effects to
humans from exposure to the chemical. The NTP will transmit the NTP-
CERHR reports to the appropriate federal and state agencies, the
public, and the scientific community.
Background
A 10-member expert panel composed of scientists from state and
federal governments, universities, and industry conducted an evaluation
of the reproductive and developmental toxicities of 1-bromopropane and
2-bromopropane [Federal Register (Vol. 66, No. 156, pp. 42548-42549,
August 13, 2001)]. Public deliberations by the panel took place
December 5-7, 2001 at the Hilton Washington-Dulles Hotel in Herndon,
Virginia. Following the December meeting, the draft expert panel
reports were revised to incorporate the panel's conclusions, and
subsequently reviewed by the Bromopropanes Expert Panel, NTP
scientists, and CERHR personnel.
1-Bromopropane is used as a solvent for fats, waxes, or resins and
as an intermediate in the synthesis of pharmaceuticals, insecticides,
quaternary ammonium compounds, flavors, or fragrances. It is also used
as a vehicle in spray adhesives and as a cold bath degreaser. 2-
Bromopropane is used as an intermediate in the synthesis of
pharmaceuticals, dyes, and other compounds; the extent of these uses
and associated human exposures is unknown. 2-Bromopropane is also
present as a contaminant in 1-bromopropane. Bromopropane are being
considered as replacement chemicals for ozone-depleting chemicals such
as hydrochlorofluorocarbons and chlorinated solvents.
Additional Information About CERHR
The NTP and the NIEHS established the NTP CERHR in June 1998
[Federal Register (Vol. 63, No. 239, p. 68782, December 1998)].
The purpose of the CERHR is to provide scientifically-based,
uniform assessments of the potential for adverse effects on
reproduction and development caused by agents to which humans may be
exposed. Further information on the CERHR's chemical review process
including how to nominate chemicals for evaluation and scientists for
the expert registry can be obtained from its Web site (http://
cerhr.niehs.nih.gov) or by contacting the CERHR directly (see contact
information above).
The CERHR also serves as a resource for information on various
environmental exposures and their potential to affect pregnancy and
child development. Its Web site (http://cerhr.niehs.nih.gov) has
information about common concerns related to fertility, pregnancy and
the health of unborn children, and links to other resources for
information about public health.
Dated: February 8, 2002.
Samuel H. Wilson,
Deputy Director, National Institute of Environmental Health Sciences.
[FR Doc. 02-5652 Filed 3-7-02; 8:45 am]
BILLING CODE 4140-01-P