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MEK inhibitor AZD8330 An orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.
Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081005100600im_/http://www.nci.nih.gov/images/spacer.gif) | ARRY-424704 | | ![](https://webarchive.library.unt.edu/eot2008/20081005100600im_/http://www.nci.nih.gov/images/spacer.gif) |
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