Localized Non-Hodgkin Lymphoma in Children and Adolescents
Disseminated Childhood B-cell Non-Hodgkin Lymphoma
Disseminated Childhood Lymphoblastic Lymphoma
Disseminated Childhood Anaplastic Large-cell Lymphoma
Recurrent Childhood Non-Hodgkin Lymphoma
Lymphoproliferative Disease Associated with a Weakened Immune System

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Standard treatment of localized non-Hodgkin lymphoma in children and adolescents is usually surgery followed by combination chemotherapy.

New treatments are being studied in clinical trials for localized non-Hodgkin lymphoma in children and adolescents.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage I childhood large cell lymphoma, stage I childhood small noncleaved cell lymphoma, stage I childhood lymphoblastic lymphoma, stage I childhood anaplastic large cell lymphoma, stage II childhood large cell lymphoma, stage II childhood small noncleaved cell lymphoma, stage II childhood lymphoblastic lymphoma and stage II childhood anaplastic large cell lymphoma.

Standard treatment for disseminated B-cell (Burkitt and Burkitt-like) non-Hodgkin lymphoma in children and adolescents is usually combination chemotherapy with CNS prophylaxis (intrathecal chemotherapy).

Monoclonal antibody therapy combined with chemotherapy is being studied in clinical trials for disseminated B-cell non-Hodgkin lymphoma in children and adolescents.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage III childhood large cell lymphoma, stage III childhood small noncleaved cell lymphoma, stage IV childhood large cell lymphoma and stage IV childhood small noncleaved cell lymphoma.

Standard treatment of disseminated lymphoblastic lymphoma in children and adolescents is usually combination chemotherapy with or without radiation therapy to the brain.

New combinations of chemotherapy, with and without CNS prophylaxis (intrathecal chemotherapy), are being studied in clinical trials for disseminated lymphoblastic lymphoma in children and adolescents.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage III childhood lymphoblastic lymphoma and stage IV childhood lymphoblastic lymphoma.

Standard treatment of disseminated anaplastic large-cell lymphoma in children and adolescents is usually combination chemotherapy with or without CNS prophylaxis (intrathecal chemotherapy).

New combinations of chemotherapy are being studied in clinical trials for disseminated anaplastic large-cell lymphoma in children and adolescents.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage III childhood anaplastic large cell lymphoma and stage IV childhood anaplastic large cell lymphoma.

Standard treatment of recurrent childhood non-Hodgkin lymphoma in children and adolescents may include the following:

• High-dose chemotherapy with stem cell transplant.
• Combination chemotherapy.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with recurrent childhood non-Hodgkin lymphoma.

Standard treatment of lymphoproliferative disease in children and adolescents with weakened immune systems may include the following:

• Surgery with or without radiation therapy.
• Combination chemotherapy.

Some of the treatments being studied in clinical trials include the following:

• Monoclonal antibody therapy combined with chemotherapy.
• Stem cell transplant followed by donor lymphocyte infusion or an infusion of T-cell lymphocytes that have been treated in the laboratory.

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