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mitomycin C A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms: | | MITC Mitocin-C MTC | | | US brand name: | | Mutamycin | | | Abbreviations: | | MITO MITO-C | | | Code name: | | NCI-C04706 | | |
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