"STEM CELLS" General Motors Cancer Research Foundation Annual Scientific Conference June 10 and 11, 2003 Full Program	National Institutes of Health DHHS NIH Clinical Center (Building 10) Masur Auditorium Bethesda, Maryland

TUESDAY, JUNE 10 8:30 am Welcome and Introductions Samuel A. Wells, Jr., M.D. President General Motors Cancer Research Foundation Professor of Surgery Duke University Medical Center Durham, North Carolina 8:40 am Keynote Address and Conference Overview "Biology of Stem and Progenitor Cells" Irving L. Weissman, M.D. Professor of Cancer Biology Professor of Pathology and Biological Sciences Stanford University School of Medicine Stanford, California Session I Developmental Biology of Stem Cells Moderator: Phillip A. Sharp, Ph.D. Chair, Awards Assembly General Motors Cancer Research Foundation Institute Professor and Director McGovern Institute for Brain Research Massachusetts Institute of Technology Cambridge, Massachusetts 9:30 - 9:50 am "Regulation of Stem Cell Self-Renewal vs. Differentiation in the Male Germ Line" Margaret T. Fuller, Ph.D. Professor and Chair Department of Developmental Biology and Genetics Chair, Department of Developmental Biology Stanford University School of Medicine Stanford, California 9:50-10:00 am Discussion 10:00-10:20 am "Regulation of Germ Line Stem Cells in C. Elegans" Judith E. Kimble, Ph.D. Department of Biochemistry College of Agricultural and Life Sciences University of Wisconsin Madison, Wisconsin 10:20-10:30 am Discussion 10:30-10:50 am Break   Session II Embryology of Stem Cells Moderator: Stuard H. Orkin, M.D. Professor and Chair Department of Pediatric Oncology Dana Farber Cancer Institute / Children's Hospital Harvard Medical School Boston, Massachusetts 10:50-11:20 am "Stem Cells and Developmental Pathways" Janet Rossant, Ph.D. Senior Investigator Samuel Lunenfeld Research Institute Department of Medical Genetics and Microbiology Mount Sinai Hospital University of Toronto Toronto, Canada 11:20-11:50 am "Pluripotency and Lineage Restriction of ES Cells" Austin Smith, Ph.D. Professor Institute for Stem Cell Research The University of Edinburgh Edinburgh, Scotland 11:50-12:20 pm "Nulcear Cloning, Stem Cells, and the Reprogramming of the Genome" Rudolph Jaenisch, Ph.D. Professor of Biology Massachusetts Institute of Technology Cambridge, Massachusetts 12:20-1:15 pm Lunch Break

Session III: Organ Stem Cells - Part I Moderator: Suzanne Cory, B.Sc., Ph.D. Director The Walter and Eliza Hall Institute of Medical Research Melbourne, Australia 1:15-1:35 pm "Control of Cell Fate and Developmental Potential in Neural Stem Cells" David J. Anderson, Ph.D. Professor of Biology California Institute of Technology Pasadena, California 1:35-1:45 pm Discussion 1:45-2:05 pm "Nuclear Transfer and Embryonic Stem Cells" Peter Mombaerts, M.D., Ph.D. Associate Professor and Head Developmental Biology/Neurogenetics Laboratory Rockefeller University New York, New York 2:05-2:15 pm Discussion 2:15-2:35 pm "Adult Neural Stem Cells" Fred H. Gage, Ph.D. Professor of Biology Laboratory of Genetics Salk Institute for Biological Studies La Jolla, California 2:35-2:45 pm Discussion   Session IV: Organ Stem Cells - Part II Moderator: Charles J. Sherr, M.D., Ph.D. Chairman, Department of Tumor Cell Biology St. Jude Children's Research Hospital Memphis, Tennessee 3:00-3:20 pm "Genomics Approaches to Retinal Development and Disease" Connie L. Cepko, Ph.D. Professor of Genetics Harvard Medical School Boston, Massachusetts 3:20-3:30 pm Discussion 3:30-3:50 pm "How Do Intestinal Stem Cells Protect their DNA From Genotoxic Damage" Christopher S. Potten, B.Sc., M.Sc., Ph.D., D.Sc. Professor of Stem Cell Biology Manchester University Epistem Limited Manchester, England 3:50-4:00 pm Discussion   Adjourn WEDNESDAY, JUNE 11 Session V: Hematopoietic Stem Cells Moderator: Alan Bernstein, Ph.D. President Canadian Institutes of Health Research Ottawa, Canada 9:00-9:20 am "Control of Hematopoietic Lineage Choice and Stem Cells" Stuart H. Orkin, M.D. Chairman, Department of Pediatric Oncology Dana Farber Cancer Institute / Children's Hospital Harvard Medical School Cambridge, Massachusetts 9:20-9:30 am Discussion 9:30-9:50 am "Stem Cell Biology in the Post-Genome Era" Ihor R. Lemischka, Ph.D. Department of Molecular Biology Princeton University Princeton, New Jersey 9:50-10:00 am Discussion 10:00-10:30 am Break   Session VI: Stem Cells and Therapy Moderator: Edison Liu, M.D. Executive Director Genome Institute of Singapore Professor of Medicine National University of Singapore Singapore 10:30-10:50 am "Complexity of the Human Stem Cell Compartment: Implications for Therapy" John E. Dick, Ph.D. Canada Research Chair in Stem Cell Biology Director, Program in Stem Cell Biology Toronto General Research Institute Toronto, Canada 10:50-11:00 am Discussion 11:00-11:20 am "Isolation and Characterization of Breast Cancer Stem Cells" Michael F. Clarke, M.D. Professor of Internal Medicine, Cell and Developmental Biology University of Michigan School of Medicine Ann Arbor, Michigan 11:20-11:30 am Discussion 11:30-11:50 am "Stem Cells from Cloned Embryos in Research and Therapy" Ian Wilmut, Ph.D., M.Sc. Professor Roslin Institute Midlothian Scotland 11:50-12:00 pm Discussion Adjourn   1:00 - 3:00 pm Laureate Lectures 2003 Charles F. Kettering Prizewinner: V. Craig Jordan, Ph.D., D.Sc. 2003 Charles S. Mott Prizewinners: Yuan Chang, Ph.D., M.D. Patrick Moore, M.D., M.P.H. 2003 Alfred P. Sloan Prizewinners: Pierre Chambon, M.D. Ronald M. Evans, Ph.D.