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pemetrexed disodium![Patient Information Patient Information](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/btn-patient-info.gif) The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/spacer.gif) | Multitargeted Antifolate | | ![](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/spacer.gif) | ALIMTA | | ![](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/spacer.gif) | MTA | | ![](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/spacer.gif) | LY231514 | | ![](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20081005073749im_/http://www.nci.nih.gov/images/spacer.gif) | - L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)
- N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt
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