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oral topotecan hydrochloride An oral formulation of the hydrochloride salt of topotecan, a semisynthetic derivative of the quinoline alkaloid camptothecin, with potential antineoplastic activity. Topotecan selectively inhibits topoisomerase I activity by stabilizing topoisomerase I-DNA covalent complexes during the S phase of the cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081005061739im_/http://www.nci.nih.gov/images/spacer.gif) | Hycamtin Capsules | | ![](https://webarchive.library.unt.edu/eot2008/20081005061739im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081005061739im_/http://www.nci.nih.gov/images/spacer.gif) | S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7] indolizino [1,2-b]quinoline-3,14-(4H,12H)-dione monohydrochloride | | ![](https://webarchive.library.unt.edu/eot2008/20081005061739im_/http://www.nci.nih.gov/images/spacer.gif) |
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