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recombinant platelet factor 4 A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, recombinant platelet factor 4 inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis; it has been shown that this agent inhibits fibroblast growth factor 2 (FGF2) angiogenic activity downstream from the FGF2 receptor. Its activity is antagonized by heparin. Recombinant platelet factor 4 may also directly inhibit the proliferation of some tumor cell types. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081006060302im_/http://www.nci.nih.gov/images/spacer.gif) | CXC-chemokine PF-4 platelet factor 4 recombinant human platelet factor 4 | | ![](https://webarchive.library.unt.edu/eot2008/20081006060302im_/http://www.nci.nih.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081006060302im_/http://www.nci.nih.gov/images/spacer.gif) | CXCL4 | | ![](https://webarchive.library.unt.edu/eot2008/20081006060302im_/http://www.nci.nih.gov/images/spacer.gif) | Acronyms: | ![](https://webarchive.library.unt.edu/eot2008/20081006060302im_/http://www.nci.nih.gov/images/spacer.gif) | rhPF4 rPF4 | | ![](https://webarchive.library.unt.edu/eot2008/20081006060302im_/http://www.nci.nih.gov/images/spacer.gif) |
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