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Birth Defects
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Key Findings > Trends and patterns of
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Trends and patterns of birth defects
and genetic diseases associated mortality in United States, 1979-1992:
An analysis of multiple-cause mortality data
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CDC scientists analyzed trends and patterns of mortality associated
with birth defects and genetic diseases in United States from 1979 through 1992.
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Population-based information on trends and patterns of
mortality associated with birth defects and genetic diseases is limited. We used Multiple-Cause Mortality Files compiled by the
National Center for Health Statistics from U.S. death certificates for 1979 through 1992 to study the trends and patterns of mortality
associated with birth defects and genetic diseases.
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The rate of birth defects-associated deaths declined
and deaths associated with genetic diseases increased slightly from 1979 to 1992.
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The declining trend in birth defects-associated deaths
may reflect 1) improvements in medical and surgical care, 2) increased use of prenatal diagnosis and subsequent pregnancy termination, and 3)
underreporting of deaths associated with birth defects.
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The increase in genetic diseases-associated deaths was
most likely related to improved recognition of some genetic diseases.
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More than 55% of birth defects-associated deaths
occurred during the decedents' first year of life. Birth defects were the leading cause of infant mortality, accounting for about 20% of all
infant deaths, but a substantial percentage of deaths of older children were also related to birth defects.
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Improved medical treatments will continue to lead to
increased survival of babies with birth defects and may shift further mortality associated with these deaths from infancy to later stages of
life.
Results published in: Genetic Epidemiology 1997;14:493-505.
(Abstract)
Date:
June 17, 2005
Content source: National Center on Birth Defects and Developmental
Disabilities
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