ARS | Publication request: Phylloquinone intake is associated with glucose metabolism in middle- and older-aged men and women

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract
Publication Acceptance Date: January 31, 2008
Publication Date: April 5, 2008
Publisher's URL: http://www.fasebj.org
Reprint URL: http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/1106.4
Citation: Yoshida, M., Booth, S.L., Meigs, J.B., Saltzman, E., Jacques, P. 2008. Phylloquinone intake. Journal of Federation of American Societies for Experimental Biology. 22:1106.4.

Technical Abstract: Animal and metabolic studies suggest that vitamin K may have a beneficial role in glucose homeostasis. The aim of this study was to examine the association between vitamin K intake and measures of glucose metabolism in a community-based sample of healthy adults. We assessed the cross-sectional associations between phylloquinone (vitamin K1) intake and glucose metabolism measures in the 2778 participants (1277 men and 1501 women; mean age, 54 y) of the Framingham Offspring Cohort Study. Phylloquinone intakes were assessed by food frequency questionnaire. Surrogate measures of glucose metabolism included fasting and 2-h post oral glucose tolerance test (OGTT) glucose and insulin, and HbA1c. Associations of glucose metabolism measures with phylloquinone intakes were assessed using the analysis of covariance with Bonferroni adjustment for the multiple outcomes. Lower phylloquinone intake was associated with higher 2-h glucose and insulin concentrations after adjustment for age, sex, waist circumference, lifestyle characteristics and diet quality (2-h glucose: 106.4 mg/dL vs. 102.1 mg/dL in the lowest compared to the highest quintile, P-trend = 0.05; 2-h insulin: 80.2 uU/mL vs. 72.0 uU/mL, P-trend = 0.02), but was not associated with fasting glucose and insulin concentrations and HbA1c. Our findings suggest a potential beneficial association of phylloquinone intake with glucose metabolism in the fed state.