ARS | Publication request: Dihydrophylloquinone Intake, a Marker of Poor Diet, Is Associated with Low Bone Mineral Density in Men

Submitted to: Experimental Biology
Publication Type: Abstract
Publication Acceptance Date: November 15, 2005
Publication Date: April 1, 2006
Publisher's URL: http://www.eb2006-online.com/pdfs/003614.PDF?PHPSESSID=f07543fef8761587d860af5e0239a3bf
Citation: Troy, L.M., Jacques, P., Hannan, M.T., Kiel, D.P., Lichtenstein, A.H., Kennedy, E.T., Booth, S.L. 2006. Dihydrophylloquinone intake, a marker of poor diet, is associated with low bone mineral density in men. Experimental Biology 2006 Annual Meeting. April 1-5, 2006. San Francisco, CA. Abstract no. 646.2.

Technical Abstract: Poor diet may result in bone loss by displacement of important nutrients involved in bone health. Dihyrdophylloquinone (dK) is formed when phylloquinone-rich plant oils are hydrogenated; major sources are commercially fried / baked foods. We hypothesized that high dK intake, as a marker of a nonhealthy dietary pattern, would be associated with low bone mineral density (BMD) in 1141 men (mean age:59y) and 1438 women (mean age: 59y) of the Framingham Offspring Study. Linear regression was used to examine crosssectional associations of dK intake from food frequency questionnaire in tertiles (<15.5, 15.5-29.5, >29.5 ug/d) and hip and spine BMD. In men, higher dK intakes were associated with lower BMD in the femoral neck (BMD g/cm2 lowest to highest tertile 0.987, 0.969, 0.959, p=.03), and trochanter (0.891, 0.874, 0.861, p=.04) adjusting for BMI, age, intakes of total energy, calcium, and vitamin D, smoking, physical activity, and osteoporosis medication use. Women had no significant associations between dK and BMD; however, there was a trend of lower BMD with higher tertiles of dK intake in post-menopausal women in the femoral neck (0.869, 0.867, 0.849) and trochanter (0.714, 0.712, 0.701). There were no associations between dK intake and spine in either men or women. High dK intake, a potential marker of a non-healthy dietary pattern, may result in low hip BMD in men.