Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Adapted from Cancer Therapy Evaluation Program, Common Terminology Criteria for Adverse Events, Version 3.0, DCTD, NCI, NIH, DHHS.
Nausea	Loss of appetite without alteration in eating habits	Oral intake decreased without significant weight loss, dehydration or malnutrition; IV fluids indicated <24 h	Inadequate oral caloric or fluid intake; IV fluids, tube feedings, or TPN indicated ≥24 h	Life-threatening consequences	Death
Vomiting	1 episode in 24 h	2–5 episodes in 24 h; IV fluids indicated <24 h	≥6 episodes in 24 h; IV fluids, or TPN indicated ≥24 h	Life-threatening consequences	Death