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Gene Info

Gene Information For:Hs. APEX1, APEX nuclease (multifunctional DNA repair enzyme) 1
Sequence ID:NM_001641
NM_080649
NM_080648

Database Links

UniGeneEntrez GeneOMIMDTPSNPViewerAssembliesSNP500CancerRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:14q11.2-q12Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:14: 19993189 - 19995765

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2819505Full LengthBC002338APEX nuclease (multifunctional DNA repair enzyme) 1
2823545Full LengthBC019291APEX nuclease (multifunctional DNA repair enzyme) 1
2905681Full LengthBC004979APEX nuclease (multifunctional DNA repair enzyme) 1
4180383Full LengthBC008145APEX nuclease (multifunctional DNA repair enzyme) 1
30709297Full LengthBC095428APEX nuclease (multifunctional DNA repair enzyme) 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001632  NP_542379  NP_542380  

Protein Infomation

RefSeq

mRNAProteinSwissProtEnzymePfam Motifs
NM_001641 NP_001632 Q5TZP7
P27695
EC 4.2.99.18 Exo_endo_phos
NM_080648 NP_542379 Q5TZP7
P27695
EC 4.2.99.18 Exo_endo_phos
NM_080649 NP_542380 Q5TZP7
P27695
EC 4.2.99.18 Exo_endo_phos

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M80261 AAA58371 P27695 EC 4.2.99.18
M81955 AAA58372 Q5TZP7
P27695
EC 4.2.99.18
S43127 AAB22977 Q5TZP7
P27695
EC 4.2.99.18
U79268 AAB50212 P27695 EC 4.2.99.18
BC002338 AAH02338 P27695 EC 4.2.99.18
BC004979 AAH04979 Q5TZP7
P27695
EC 4.2.99.18
BC008145 AAH08145 P27695 EC 4.2.99.18
BC019291 AAH19291 P27695 EC 4.2.99.18
BC095428 AAH95428 Q5TZP7
P27695
EC 4.2.99.18
BT007236 AAP35900 P27695 EC 4.2.99.18
BT020133 AAV38935 Q5TZP7
P27695
EC 4.2.99.18
DQ891814 ABM82740    
DQ894998 ABM85924    
D90373 BAA14381 P27695 EC 4.2.99.18
AK291100 BAF83789 Q5TZP7  
X59764 CAA42437 P27695 EC 4.2.99.18
BX161454 CAD61917 Q5TZP7
P27695
EC 4.2.99.18

Homologs (from HomoloGene)

Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens APEX1 NP_001632 M.musculus Apex1 11792 Gene Info NP_033817 95
R.norvegicus Apex1 79116   NP_077062 94
A.gambiae AgaP_AGAP009587 1278924   XP_318609 55
D.melanogaster Rrp1 33500   NP_476841 53
C.elegans exo-3 173069   NP_001021584 46
A.thaliana ARP 818744   NP_181677 46

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta


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