FRIDAY, Nov. 9 (HealthDay News) -- People diagnosed with rheumatoid arthritis run a greater risk of developing heart disease.

But that risk can be spotted and hopefully modified by using the same criteria used to identify heart-disease risk in the general population, a new study suggests.

Those screening checks include high blood pressure, high cholesterol, older age, and family history of cardiovascular illness. And people diagnosed with rheumatoid arthritis (RA) should be screened using those risk factors as soon as possible following their diagnosis of RA, the study authors said.

"The bottom-line is that RA patients are at increased risk of heart disease," said lead researcher Dr. Hilal Maradit Kremers, a research associate with the Mayo Clinic Department of Health Sciences Research in Rochester, Minn.

"But we need to know how can we predict which RA patients are at a higher risk than others, so that we can then put more effort in the prevention of heart disease in these people," she added. "And so, here we attempted to do just that, by using a typical cardiovascular risk profile to predict heart disease among these patients."

Kremers and her colleagues presented their findings this week at the American College of Rheumatology annual meeting, in Boston.

The study findings follow a 2005 Mayo Clinic report that suggested that the increase in heart disease risk among RA patients may be due to the systemic inflammation brought on by the disease, which, in turn, prompts arterial plaque to form blood clots. The new findings also come on the heels of a Mayo Clinic study released last month that said RA patients are more than twice as likely to develop heart failure over a 15-year period than people who don't have the disease.

According to the Arthritis Foundation, rheumatoid arthritis is a chronic and often disabling disease with no known cause or cure that affects just over 2 million Americans. It's characterized by inflammation of the lining of the joints and, over time, can lead to joint damage, severe pain, and immobility.

Treatments -- such as nonsteroidal anti-inflammatories, analgesics and physical therapy -- focus primarily on controlling pain and limiting inflammation and joint destruction.

For the new study, Kremers and her colleagues set out to predict the onset of heart disease over the course of a 10-year period among more than 1,100 people, approximately half of whom had just been diagnosed with RA. The patients were 57 years old, on average, and nearly three-quarters were women.

The patients were evaluated on standard indicators for heart disease risk, as detailed by the American Heart Association. The indicators included: gender; having a family history of heart disease; having diabetes; and/or being black. Patients were also examined for other risk factors, such as high cholesterol and high blood pressure. Risky lifestyle habits -- including smoking, lack of exercise, and being overweight -- were also considered, the researchers said.

Based on the risk-assessment scores, the researchers assigned the patients to one of five different risk categories for heart disease -- ranging from very low to very high risk. Then the patients were tracked for an average of 12 to 14 years, during which time all incidences of heart attack, heart failure, heart surgeries, and cardiovascular-related deaths were noted.

The researchers found that while 85 percent of the RA patients between the ages of 50 and 59 had an intermediate or high risk for developing heart disease within 10 years of diagnosis, just 27 percent of comparable non-RA patients did. Among patients between the ages of 60 and 69 at the start of the study, 100 percent of the RA patients had an intermediate or high risk for heart disease, compared with 79 percent of non-RA patients.

When looking at just "high risk" among the 60 to 69 age group, the difference was even more dramatic: 85 percent for RA patients, compared to just 40 percent for non-RA patients.

The researchers concluded that more than half of RA patients 50 to 59, and all RA patients over the age of 60, had a 10 percent or greater risk of developing heart disease within 10 years of an RA diagnosis.

In light of the findings, the Mayo researchers are encouraging doctors to conduct heart-disease assessment screenings similar to the ones used in the study for each of their RA patients. These screenings should be done as soon as possible following an RA diagnosis and prevention strategies put into place, the researchers said.

"By simply doing the things that we already know, such as measuring blood pressure, blood sugars, and cholesterol -- all the standard things that we look at for the general population -- we can help identify the risk for a major cardiovascular event among the RA population," Kremers said.

Dr. Hayes Wilson, chief of rheumatology at Piedmont Hospital in Atlanta, said he endorsed the Mayo researchers' work.

"Anything that helps us characterize and categorize risk factors helps us in the treatment of the disease," he said. "And, until we can figure out what the smoking gun is, hopefully this advice will help us prevent cardiovascular disease or related diseases by helping RA patients better appreciate the risks they face."

More information

To learn more about rheumatoid arthritis, visit the Arthritis Foundation  .

WEDNESDAY, Nov. 28 (HealthDay News) -- Experimental compounds aimed at treating diseases such as type 2 diabetes show promise, scientists say.

These "novel chemical entities" activate SIRT1, a gene controlling the aging process, the researchers report in the Nov. 29 issue of Nature.

In obese mice, these compounds improved insulin sensitivity, lowered plasma glucose levels, and increased the function of mitochondria (the powerhouse of cells).

In rats, the compounds improved whole body glucose homeostasis and insulin sensitivity in fat tissue, skeletal muscle, and the liver.

The experimental compounds were developed and tested by Sirtris Pharmaceuticals Inc., in Cambridge, Mass.

"The new drug candidates represent a significant milestone because they are the first molecules that have been designed to act on genes that control the aging process. For this reason, we feel they have considerable potential to treat diseases of aging such as Type 2 diabetes," Dr. Cristoph Westphal, chief executive officer and vice chair of Sirtris Pharmaceuticals, said in a prepared statement.

He said the results from the rodent tests highlight the potential of these new compounds to treat aging-related diseases, and the company hopes to begin human studies of one of the compounds in the first half of 2008.

More information

The U.S. Centers for Disease Control and Prevention looks at healthy aging.

FRIDAY, Nov. 9 (HealthDay News) -- Older adults aren't more prone to distraction than younger adults when they're asked to focus their attention on a sight or sound, or when asked to switch their attention from one sense to another, a U.S. study finds.

Previous research suggested that older adults were more easily distracted than younger adults.

"There are two kinds of attention we were interested in studying -- voluntary attention and involuntary attention," lead researcher Dr. Paul J. Laurienti, associate professor of radiology at Wake Forest University Baptist Medical Center in Winston-Salem, N.C., said in a prepared statement.

"We all know that we can choose to focus on one sense and ignore another. For instance, you might be able to ignore the sounds of the television while you read the paper. But sometimes, a very salient stimulus can capture your attention anyway -- for instance, if the fire alarm went off while you were reading the paper."

This study included 48 people (divided into two groups -- ages 18 to 38 and ages 65 to 90) who were asked to perform a series of sight/sound tasks that measured how quickly the participants were able to switch from one sense to the other. The participants were told what to expect (voluntary attention) in some tests but not told what to expect (involuntary attention) in other tests.

The results "showed that older adults still successfully engaged their attention, both in terms of speeding up and slowing down," co-author Christina E. Hugenschmidt, a Ph.D. candidate at the university's School of Medicine, said in a prepared statement. "Older adults were also quite similar to younger adults in how much of their attention was captured involuntarily. Even as we age, this study suggests that the brain's ability to engage multisensory attention remains intact."

The findings were to be presented at the Society for Neuroscience annual meeting in San Diego.

More information

The AGS Foundation for Health in Aging discusses age-related psychological and social issues.