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Imatinib is used to treat certain types of leukemia (cancer that begins in the white blood cells) and other cancers of the blood cells. Imatinib is also used to treat gastrointestinal stromal tumors (GIST; a type of tumor that grows in the walls of the digestive passages and may spread to other parts of the body). Imatinib is also used to treat dermatofibrosarcoma protuberans (a tumor that forms under the top layer of skin) when the tumor cannot be removed surgically, has spread to other parts of the body, or has come back after surgery. Imatinib is in a class of medications called protein-tyrosine kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.
Imatinib comes as a tablet to take by mouth. It is usually taken with a meal and a large glass of water once or twice a day. Take imatinib at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take imatinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are unable to swallow imatinib tablets, you may place all of the tablets that you need for one dose into a glass of water or apple juice. Use 50 mL (a little less than 2 ounces) of liquid for each 100 mg tablet and 100 mL (a little less than 4 ounces) of liquid for each 400 mg tablet. Stir with a spoon until the tablets crumble completely and drink the mixture immediately.
If your doctor has told you to take 800 mg of imatinib, you should take two of the 400 mg tablets. Do not take 8 of the 100 mg tablets. The tablet coating contains iron, and you will receive too much iron if you take 8 of the 100 mg tablets.
Your doctor may increase or decrease your dose of imatinib during your treatment. This depends on how well the medication works for you and on the side effects you experience. Talk to your doctor about how you are feeling during your treatment. Continue to take imatinib even if you feel well. Do not stop taking imatinib without talking to your doctor.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Before taking imatinib,
Talk to your doctor about drinking grapefruit juice or eating grapefruit while taking this medication.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Imatinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:
Imatinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to imatinib.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised -
Last Reviewed - 08/01/2007
AHFS® Consumer Medication Information. © Copyright, 2008. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.
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|Page last updated: 09 September 2008|