 |
|
Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
Alternate Title
Basic Trial Information
Trial Description
Purpose
Eligibility
Treatment/Intervention
Trial Contact Information
Related Information
Registry Information
Alternate Title
Phase III Randomized Study of Stereotactic Radiosurgery With Versus Without Whole-Brain Radiotherapy in Patients With Cerebral Metastases
Basic Trial Information
|
Phase
|
|
|
|
Type
|
|
|
|
Status
|
|
|
|
Age
|
|
|
|
Sponsor
|
|
|
|
Protocol IDs
|
|
|
|
Phase III
|
|
|
|
Treatment
|
|
|
|
Active
|
|
|
|
18 and over
|
|
|
|
NCI
|
|
|
|
NCCTG-N0574
N0574, ACOSOG-N0574, NCT00377156
|
|
|
Special Category:
NCI Web site featured trial, CTSU trial Trial Description Purpose: Stereotactic radiation therapy can send x-rays directly to the tumor and cause less damage to normal tissue. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known whether stereotactic radiation therapy is more effective with or without whole-brain radiation therapy in treating patients with brain metastases.
This randomized phase III trial is studying stereotactic radiation therapy and whole-brain radiation therapy to see how well they work compared with stereotactic radiation therapy alone in treating patients with brain metastases.
Eligibility: Eligibility criteria include the following: Final eligibility for a clinical trial is determined by the health professionals conducting the trial. Treatment/Intervention: Patients will be randomly assigned (have an equal chance of being placed) to one of two treatment groups. Patients in group one will undergo stereotactic radiation therapy. Patients in group two will undergo stereotactic radiation therapy. Beginning no more than 2 weeks later, they will undergo radiation therapy to the entire brain 5 days a week for 2½ weeks. Quality of life, ability to function independently, and ability to think and reason will be assessed before the first treatment; at the beginning of each treatment; at 6 and 12 weeks; at 6, 9, 12, and 16 months; and once a year until year 5.
Important: For more details about this trial, refer to the Health Professional version of the trial summary. If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on
NCI's Web site.
Trial Contact Information
Trial Lead Organizations North Central Cancer Treatment Group | | | | Paul Brown, MD, Protocol chair | | | | | Kurt Jaeckle, MD, Protocol co-chair | | | | | Richard Deming, MD, Protocol co-chair | | | | | Elana Farace, PhD, Protocol co-chair | | | | | Bruce Pollock, MD, Protocol co-chair | | | |
American College of Surgeons Oncology Group | | | | Anthony Asher, MD, FACS, Protocol chair | | | | | Fred Barker, MD, Protocol co-chair | | | Ph: 617-724-8772 ; 877-726-5130 |
| |
Eastern Cooperative Oncology Group | | | | Larry Kleinberg, MD, Protocol chair | | | |
Radiation Therapy Oncology Group | | | | Anthony Asher, MD, FACS, Protocol chair | | | |
Trial Sites
|
|
|
|
| U.S.A. |
|
| Alabama |
|
| |
Mobile |
|
| | | | | Providence Cancer Center at Providence Hospital |
| | | Paul Schwarzenberger, MD | |
|
| Arizona |
|
| |
Scottsdale |
|
| | | | Mayo Clinic Scottsdale |
| | | Clinical Trials Office - All Mayo Clinic Locations | |
|
| California |
|
| |
Auburn |
|
| | | | Auburn Radiation Oncology |
| | | Anthony Pu, MD | |
|
| |
Cameron Park |
|
| | | Radiation Oncology Centers - Cameron Park |
| | | Anthony Pu, MD | |
|
| |
Carmichael |
|
| | | Mercy Cancer Center at Mercy San Juan Medical Center |
| | | Anthony Pu, MD | |
|
| |
Roseville |
|
| | | Radiation Oncology Center - Roseville |
| | | Anthony Pu, MD | |
|
| |
Sacramento |
|
| | | Mercy General Hospital |
| | | Anthony Pu, MD | |
| | | Radiological Associates of Sacramento Medical Group, Incorporated |
| | | Anthony Pu, MD | |
|
| |
Vacaville |
|
| | | Solano Radiation Oncology Center |
| | | Anthony Pu, MD | |
|
| Delaware |
|
| |
Newark |
|
| | | | CCOP - Christiana Care Health Services |
| | | Clinical Trial Office - CCOP - Christiana Care Health Services | |
|
| Florida |
|
| |
Boca Raton |
|
| | | | Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus |
| | | Clinical Trials Office - Eugene M. and Christine E. Lynn Cancer Institute | |
|
| |
Gainesville |
|
| | | University of Florida Shands Cancer Center |
| | | Clinical Trials Office - University of Florida Shands Cancer Center | |
|
| |
Jacksonville |
|
| | | Baptist Cancer Institute - Jacksonville |
| | | Clinical Trials Office - Baptist Cancer Institute - Jacksonville | |
| | | Mayo Clinic - Jacksonville |
| | | Clinical Trials Office - All Mayo Clinic Locations | |
|
| Georgia |
|
| |
Atlanta |
|
| | | | Saint Joseph's Hospital of Atlanta |
| | | Clinical Trials Office - Saint Joseph's Hospital of Atlanta | |
|
| Illinois |
|
| |
Arlington Heights |
|
| | | | Northwest Community Hospital |
| | | Stephen Nigh, MD | |
|
| |
Urbana |
|
| | | CCOP - Carle Cancer Center |
| | | Clinical Trials Office - CCOP - Carle Cancer Center | |
|
| Indiana |
|
| |
Fort Wayne |
|
| | | | Parkview Regional Cancer Center at Parkview Health |
| | | David Hornback, MD | |
|
| Iowa |
|
| |
Des Moines |
|
| | | | John Stoddard Cancer Center at Iowa Methodist Medical Center |
| | | Clinical Trials Office - John Stoddard Cancer Center at Iowa Methodist Medical Center | |
| | | Mercy Cancer Center at Mercy Medical Center - Des Moines |
| | | Roscoe Morton, MD, FACP | |
|
| Kansas |
|
| |
Kansas City |
|
| | | | Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center |
| | | Clinical Trials Office - Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center | |
|
| Michigan |
|
| |
Royal Oak |
|
| | | | William Beaumont Hospital - Royal Oak Campus |
| | | Clinical Trials Office - William Beaumont Hospital - Royal Oak Campus | |
|
| Minnesota |
|
| |
Saint Cloud |
|
| | | | CentraCare Clinic - River Campus |
| | | Harold Windschitl, MD | |
|
| Nebraska |
|
| |
Omaha |
|
| | | | Immanuel Medical Center |
| | | Gamini Soori, MD, FACP, FRCP, MBA | |
|
| New Mexico |
|
| |
Albuquerque |
|
| | | | Lovelace Medical Center - Downtown |
| | | Benny Liem, MD | |
|
| New York |
|
| |
Buffalo |
|
| | | | Roswell Park Cancer Institute |
| | | Clinical Trials Office - Roswell Park Cancer Institute | |
|
| |
Rochester |
|
| | | James P. Wilmot Cancer Center at University of Rochester Medical Center |
| | | Paul Okunieff, MD | |
|
| North Carolina |
|
| |
Charlotte |
|
| | | | Blumenthal Cancer Center at Carolinas Medical Center |
| | | Clinical Trials Office - Blumenthal Cancer Center at Carolinas Medical Center | |
|
| |
Greenville |
|
| | | Leo W. Jenkins Cancer Center at ECU Medical School |
| | | Clinical Trials Office - Leo W. Jenkins Cancer Center at ECU Medical School | |
|
| |
Winston-Salem |
|
| | | Forsyth Regional Cancer Center at Forsyth Medical Center |
| | | Clinical Trials Office - Forsyth Regional Cancer Center at Forsyth Medical Center | |
| | | Wake Forest University Comprehensive Cancer Center |
| | | Clinical Trials Office - Wake Forest University Comprehensive Cancer Center | |
|
| Ohio |
|
| |
Akron |
|
| | | | Summa Center for Cancer Care at Akron City Hospital |
| | | Clinical Trials Office - Akron City Hospital | |
|
| |
Cleveland |
|
| | | Cleveland Clinic Taussig Cancer Center |
| | | Clinical Trials Office - Cleveland Clinic Taussig Cancer Center | |
|
| Oklahoma |
|
| |
Tulsa |
|
| | | | Natalie Warren Bryant Cancer Center at St. Francis Hospital |
| | | Mark Olsen, MD, PhD | |
|
| Pennsylvania |
|
| |
Allentown |
|
| | | | Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest |
| | | Suresh Nair, MD | |
|
| |
Hershey |
|
| | | Penn State Cancer Institute at Milton S. Hershey Medical Center |
| | | Clinical Trials Office - Penn State Cancer Institute at Milton S. Hershey Medical Center | |
| | Email:
CTO@hmc.psu.edu |
|
| |
Pittsburgh |
|
| | | Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital |
| | | Judith Figura, MD | |
|
| South Dakota |
|
| |
Sioux Falls |
|
| | | | Sanford Cancer Center at Sanford USD Medical Center |
| | | Clinical Trials Office - Sanford Cancer Center | |
|
| Utah |
|
| |
Salt Lake City |
|
| | | | LDS Hospital |
| | | R. Jeffrey Lee, MD | |
|
| Virginia |
|
| |
Charlottesville |
|
| | | | University of Virginia Cancer Center |
| | | Jason Sheehan | | Ph: | 434-924-9333 | | 800-223-9173 |
|
|
Related Information Featured trial article
PDQ® clinical trial ACOSOG-Z0300
| Registry Information | | | Official Title | | Phase III Randomized Trial of the Role of Whole Brain Radiation Therapy in Addition to Radiosurgery in Patients with One to Three Cerebral Metastases | | | Trial Start Date | | 2006-07-28 | | | Trial Completion Date | | 2011-07-02 (estimated) | | | Registered in ClinicalTrials.gov | | NCT00377156 | | | Date Submitted to PDQ | | 2006-07-14 | | | Information Last Verified | | 2008-10-31 | | | NCI Grant/Contract Number | | CA25224 |
|
 |
